不同方案治疗肿瘤骨转移性疼痛的临床效果比较  

Comparative Study of the Clinical Effects of Different Regimens for Metastatic Bone Cancer Pain

作　　者：苏世先 刘前前 江美林 

机构地区：[1]山东省青岛市城阳区人民医院,266109

出　　处：《实用癌症杂志》2016年第10期1728-1730,共3页The Practical Journal of Cancer

摘　　要：目的比较不同方案治疗肿瘤骨转移性疼痛的临床效果。方法将80例肿瘤骨转移性疼痛患者按照随机数字表法分为实验组和对照组,各40例。实验组患者采用唑来膦酸联合化疗方案治疗,对照组患者仅给予化疗诊治。分析2组患者疼痛缓解状况,比较2组患者治疗前后AKP、NRS以及KPS的变化,观察2组患者治疗后不良反应的状况。结果治疗前,2组患者的AKP值、NRS评分以及KPS评分相差不大（P〉0.05）。经过治疗,实验组患者AKP值与NRS评分均较治疗前以及对照组患者治疗后显著降低,KPS较治疗前以及对照组患者显著提高,均具有统计学意义（P〈0.05）。经过治疗,实验组发生6例恶心呕吐,2例食欲不振,3例皮疹,1例发热,5例嗜睡等不良症状;对照组发生5例恶心呕吐,3例食欲不振,4例皮疹,2例发热,4例嗜睡。2组患者不良反应均未经处理,3~5 d后自行消失,均未见严重不良反应发生。结论唑来膦酸联合化疗方案治疗肿瘤骨转移性疼痛,能够显著提高疼痛缓解的有效率,且显著降低AKP值与NRS评分,提高KPS评分,具有一定的安全性。Objective To analyze the clinical effect of different regimens for metastatic bone cancer pain.Methods 80 patients with metastatic bone pain,according to the random number table,were divided into the experimental group and the control group,40 cases in each.The experimental group were treated with zoledronic acid combined with chemotherapy,the control group only received chemotherapy treatment.Pain condition relief of the 2 groups were analyzed,AKP,NRS and the change of KPS of the 2 groups were compared before and after treatment,adverse conditions of the 2 groups were observed.Results Before treatment,AKP value,NRS score and KPS score of the 2 groups had no significant difference（P〉0.05）.After treatment,NRS score and AKP value of the experimental group than before treatment and the control group after treatment decreased significantly,KPS of the experimental group than before treatment and the control group after treatment significantly increased（P〈0.05）.After treatment,the experimental group had 6 cases of nausea and vomiting,loss of appetite 2 cases,3 cases of rash,1 case of fever,lethargy and other adverse symptoms 5 cases; the control group had 5 cases of nausea and vomiting,loss of appetite 3 cases,4 cases of rash,fever 2 cases,4 cases of lethargy.Side effects of both groups were untreated and went away in 3-5 d,showed no serious adverse reactions.Conclusion Zoledronic acid and chemotherapy for metastatic bone cancer pain can significantly improve the efficacy of pain relief,and significantly reduce the AKP score and NRS score,improve KPS score,it has certain security.

关 键 词：唑来膦酸 化疗 止痛疗效 评分 不良反应 

分 类 号：R730.5[医药卫生—肿瘤]