microRNA参与体细胞重编程诱导分化为神经细胞的研究进展  

Research Progress of microRNA Involved in Somatic Cells Reprogramming Induced to Differentiate into Neural Cells

作　　者：李媛媛[1,2] 王跃嗣[1,2] 

机构地区：[1]滨州医学院药学院,烟台264003 [2]滨州医学院医药研究中心,烟台264003

出　　处：《中国细胞生物学学报》2016年第9期1180-1184,共5页Chinese Journal of Cell Biology

基　　金：国家自然基金(批准号:30801353);山东省泰山学者支持计划资助的课题~~

摘　　要：神经退行性疾病是临床上常见的疾病,目前其治疗只停留在药物治疗及手术治疗阶段。由于神经细胞是难以再生的一种细胞类型,寻找替代神经细胞对神经退行性疾病移植治疗具有重要意义。现有研究表明,MSC(mesenchymal stem cell)、ESC(embryonic stem cell)或i PSC(induced pluripotent stem cell)能在体外分化为神经细胞,干细胞治疗神经退行性疾病具有良好的临床前景,但目前受到神经分化效率低、免疫排斥等因素的限制。研究显示,micro RNA具有参与神经发育和分化等作用,且具有重编程神经干细胞并治疗神经退行性疾病的能力。因此,该文就micro RNA参与体细胞的重编程诱导分化为神经细胞机制与作用等作一简要综述,探讨micro RNA对体细胞重编程调控作用和临床应用前景。Neurodegenerative disease is a common clinical disease. The treatment of these diseases only stays in the stage of drug therapy and surgery. Since the nerve cell is difficult to regeneration, it is very important to develop a new source of nerve cells for transplantation in the treatment of these diseases. The studies have demonstrated that mesenchymal stem cell（MSC）, embryonic stem cell（ESC） or induced pluripotent stem cell（i PSC） could differentiate into neural cells in vitro. Stem cell replacement treatment of neurodegenerative diseases will have excellent prospects. However, the limit of the low efficiency of nervous differentiation and the immune rejection has become an obstacle to the clinical application research. Studies have shown that micro RNA（mi RNA） has participation in nervous system development and differentiation and so on, and have the ability of reprogramming neural stem cells and treatment of neurodegenerative diseases. Therefore, this review makes a brief overview of mi RNA involved in somatic cells reprogramming into neural cell＇s mechanisms and the roles of mi RNA reprogramming in the clinical application prospects.

关 键 词：神经退行性疾病 MICRORNA 神经干细胞 重编程 

分 类 号：R741[医药卫生—神经病学与精神病学]