ATRX在不同类型中枢神经系统肿瘤中的表达及其在鉴别诊断中的意义  

Expression of ATRX in different central nervous system tumors and the usefulness in differential diagnosis

作　　者：褚明亮[1] 张著学[1] 张赟[1] 杨迎春[1] 沈和德 易韦[1] CHU Ming-liong ZHANG Zhu-xue ZHANG Yun YANG Ying-chun SHEN He-de YI Wei.(Department of Pathology, Guizhou Provincial People＇s Hospital, Guiyang 550002, Chin)

机构地区：[1]贵州省人民医院病理科,贵阳市550002

出　　处：《实用医学杂志》2016年第18期3026-3029,共4页The Journal of Practical Medicine

基　　金：贵州省科学技术基金项目(编号:黔科合J字[2015]2086号);贵州省科技厅项目(编号:黔科合字LH[2014]7017号)

摘　　要：目的:探讨α-地中海贫血/精神发育迟滞综合征X染色体相关基因(ATRX)在多种中枢神经系统肿瘤中的表达及意义。方法:采用免疫组织化学法检测ATRX在星形胶质细胞瘤、少突胶质细胞瘤、胶质母细胞瘤、室管膜瘤及脑膜瘤组织标本中的表达,分析其在各种病变中的意义。结果:ATRX表达阳性率在星形胶质细胞瘤组织中为16%(4/25),而在少突胶质细胞瘤组织中为86%(18/21),胶质母细胞瘤组织中为90%(19/21),室管膜瘤组织中为95%(19/20),脑膜瘤组织中为100%(20/20)。结论:ATRX的表达缺失主要发生在星形胶质细胞瘤中,可用来辅助诊断星形胶质细胞瘤病变。Objective To investigate the expression of α-thalassemia/mental retardation syndrome X- linked （ATRX） in different central nervous system tumors and the meaningness in differential diagnosis. Methods Expression of ATRX protein was determined by immunohistoehemistry in astrocytomas, oligodendrogliomas, glioblastomas, ependymomas and meningiomas. Results Positive expression levels of ATRX in astrocytomas were significantly lower than those in oligodendrogliomas,glioblastomas, ependymomas and meningiomas （all P 〈0.01）. Conclusion The loss of ATRX was mainly occurred in astrocytomas, which could be as a astrocytoma marker in diagnosis.

关 键 词：中枢神经系统肿瘤 ATRX 

分 类 号：R739.4[医药卫生—肿瘤]