气道内金属支架置入术联合放射性粒子植入对比放疗治疗肺癌气道狭窄的临床研究  

Metal stent plus radioactive ^(125)I seed implantation for the treatment of airway stenosis caused by pulmonary carcinoma: clinical comparison with metal stent plus radiotherapy

作　　者：龚正[1] 张彩云[1] 王艳华 龚萍 董传江[1] 陈世雄[1] 

机构地区：[1]三峡大学呼吸病研究所、宜昌市中心人民医院呼吸科,湖北宜昌443003 [2]兴山县人民医院 [3]秭归县人民医院

出　　处：《介入放射学杂志》2016年第10期870-873,共4页Journal of Interventional Radiology

基　　金：湖北省卫生计生委科研项目(WJ2015MB173);宜昌市卫生科技项目(A14301-06);宜昌市中心人民医院科研发展基金(KFJ2013009)

摘　　要：目的比较气道内金属支架置入术联合应用放射性粒子与气道内金属支架置入术联合放疗治疗肺癌患者气道狭窄的疗效及不良反应。方法将46例肺癌患者分为两组,治疗组和对照组各23例。治疗组采用气道内金属支架置入术联合应用放射性粒子,对照组采用气道内金属支架置入术联合放疗。观察两组6个月、1年、2年生存率,呼吸困难间隔时间,肿瘤体积缩小比例,2年内患者气管镜治疗次数及住院天数等疗效;以及治疗后发生消化道反应、白细胞减少等不良反应。结果两组患者6个月生存率无显著差异,治疗组患者1年生存率、2年生存率高于对照组。治疗组患者肿瘤体积缩小比例、再发呼吸困难间隔时间长于对照组。2年内治疗组患者气管镜治疗次数及住院天数少于对照组。结论气道内金属支架置入术联合局部放射性粒子植入治疗肺癌气道狭窄的疗效优于气道内金属支架置入术联合放疗。Objective To compare the therapeutic results and adverse effects of metal stent plus radioactive ^125I seed implantation with those of metal stent plus radiotherapy in treating airway stenosis caused by pulmonary carcinoma. Methods A total of 46 patients with pulmonary carcinoma were divided into the study group （n=23） and the control group （n=23）. Metal stent plus radioactive ^125I seed implantation was employed for the patients of the study group, while metal stent plus radiotherapy was adopted for the patients of the control group. The 6-month, one-year and two-year survival rate, the interval time of dyspnea, the reduction ratio of tumor volume, the frequency of bronchoscopic treatment and the hospitalization days within two years, the post- treatment adverse reactions, such as gastrointestinal reactions, leukopenia, etc. were recorded. Results No statistically significant difference in 6-month survival rate existed between the two groups; the one-year and two-year survival rates of the study group were higher than those of the control group. The reduction ratio of tumor volume in the study group was higher than that in the control group, and the interval time of dyspnea in the study group was longer than that in the control group. Within two years after the treatment, the times of bronchoscopic treatment and the hospitalization days of the study group were less than those of the control group. Conclusion In treating airway stenosis caused by pulmonary carcinoma,metal stent plus radioactive ^125I seed implantation is superior to metal stent plus radiotherapy.

关 键 词：金属支架 肺肿瘤 ^125I放射性粒子 

分 类 号：R734.2[医药卫生—肿瘤]