青岛市中老年双生子轻度认知功能障碍患病率及其与血压的关系  

Relationship between the prevalence of MCI and blood pressure in the middle-aged and elderly twins in Qingdao

作　　者：李吉祝[1] 王金东[1] 徐春生 孔伶俐[1] 王春霞[1] LI Ji - zhu WANG Jin - dong XU Chun - sheng KONG Ling - li WANG Chun - xia(Qingdao Mental Health Center, Qingdao 266034 , China Qingdao Municipal Center For Disease Control and Prevention , Qingdao 266033 , China)

机构地区：[1]青岛市精神卫生中心,山东青岛266034 [2]青岛市疾病控制与预防中心,山东青岛266033

出　　处：《四川精神卫生》2016年第5期453-456,共4页Sichuan Mental Health

摘　　要：目的调查青岛市中老年双生子轻度认知功能障碍（ MCI ）的患病率及同病率,并探讨其患病率与血压的关系,为预防MCI提供参考.方法从青岛市双生子库中招募384对年龄≥40岁的中老年双生子,其中同卵双生子244对 ,异卵双生子 140对.采用一般情况调查表收集其性别、年龄、收缩压、舒张压等资料.采用北京版蒙特利尔认知评价量表（ MoCA）评定其认知功能.结果青岛市中老年双生子人群MCI患病率为84.38% ;同卵和异卵双生子MCI患病率分别为83.40%、 86.07% ;MCI同病率为81.51% , 同卵和异卵双生子MCI同病率分别为81.97% 、80.71% .高收缩压组MCI患病率高于非高收缩压组（χ^2 =20. 590, P〈0. 01）,高舒张压组MCI患病率高于非高舒张压组（χ^2 = 10.041, P 〈0.01 ）.结论 青岛市中老年双生子MCI患病率较高,双生子的不同卵型可能与MCI同病率无关,高血压可能增加患MCI的风险.Objective To investigate the prevalence and concordance rate of mild cognitive impairment（ MCI） in the middle and old age twins in Qingdao. To explore the relationship between the prevalence of MCI and blood pressure, so that to provide reference for preventing MCI. Methods 384 pairs of twins over 40 years old were collected from Qingdao twins library. There were 244 pairs of monozygotic twins and 140 pairs of fraternal twins. The gender, age, systolic pressure and diastolic pressure were investigated with the general situation questionnaire. Beijing version of the Montreal Cognitive Assessment （ MoCA） was used to assess the cognitive function. Results The prevalence of MCI was 84. 38% in the middle - aged and elderly twins in Qingdao. The prevalence of MCI in monozygotic twins and fraternal twins were 83. 40% and 86. 07% ,respectively. The concordance rate of MCI was 81. 5 1% . The concordance rate of MCI was 81. 97% in monozygotic twins and 80. 71% in fraternal twins. The prevalence of MCI was higher in individuals with high systolic blood pressure than that in individuals without high systolic blood pressure（χ^2 = 20. 590, P 〈 0. 01） . The prevalence of MCI was higher in individuals with high diastolic blood pressure than that in individuals without high diastolic blood pressure（χ^2 = 10. 0 4 1 , P 〈0 . 01 ） . Conclusion The prevalence of MCI of the middle and old age twins in Qingdao is high. There is no relationship between concordance rate of MCI and monozygotic or fraternal twins, and hypertension may increase the risk of MCI.

关 键 词：中老年 双生子 轻度认知功能障碍 患病率 收缩压 舒张压 

分 类 号：R749[医药卫生—神经病学与精神病学]