2型糖尿病骨质疏松研究进展  

The research progress of type 2 diabetes osteoporosis

作　　者：刘帼静[1,2] 呼晓雷[1,2] 何发忠[1,2] 张伟[1,2] 

机构地区：[1]中南大学湘雅医院临床药理研究所 [2]中南大学临床药理研究所遗传药理湖南省重点实验室

出　　处：《中国药理学通报》2016年第10期1333-1336,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81273595);国家高技术研究发展计划(863计划)资助项目(No 2012AA02A518)

摘　　要：糖尿病主要是由于胰岛素分泌不足或者胰岛素抵抗引起的体内血糖升高。糖尿病骨质疏松是一种慢性的糖尿病并发症,一般由于胰岛素绝对或相对不足以及内分泌功能紊乱引起激素失衡、钙磷代谢紊乱而导致的骨密度下降及骨微观结构改变。由于现代人摄入营养物质过剩、运动量下降以及环境变化等因素,引起糖尿病的发生率增加。2型糖尿病的发生率占糖尿病总数的90%左右,且2型糖尿病的患者骨折的发生率明显上升。该文就2型糖尿病对骨影响的研究进展进行综述。Diabetes is a kind of metabolic syndrome, always hap-pening in the case of insufficient secretion of insulin or insulin resistance, inducing the increase of blood glucose. While, dia-betic osteoporosis is a kind of chronic diabetic complications, which happens when insulin secretion is absolutely or relatively insufficient and then the insufficiency induces imbalance of hor-mone, calcium phosphorus metabolic disorders, thus leading to the decline of bone mineral density and change of bone micro-structure. The overnutrition, less exercise and the environment change lead to the increased incidence of diabetes. For all the diabetes, type 2 diabetes accounts for about 90%. Patients with type 2 diabetes show the increasing risk of fracture. This review summarizes the recent advances in the influence of type 2 diabe-tes on bones.

关 键 词：2型糖尿病 骨质疏松 高糖 胰岛素 药物 

分 类 号：R-05[医药卫生] R336