β淀粉样蛋白跨血脑屏障转运机制研究进展  

Research progress on transport mechanism of amyloid beta-peptides across blood-brain barrier

作　　者：张海静[1,2,3] 赵春晖[1,2,3] 张文生[1,2,3] 

机构地区：[1]北京师范大学中药资源保护与利用北京市重点实验室,北京100088 [2]教育部天然药物工程研究中心,北京100088 [3]北京师范大学资源学院,北京100875

出　　处：《中国药理学通报》2016年第10期1348-1352,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274118);国家科技部"重大新药创制"科技重大专项资助项目(No 2012ZX09103-201);中央高校基本科研业务费项目(No 2015KJJC A05)

摘　　要：β淀粉样蛋白(amyloid beta-peptides,Aβ)是阿尔茨海默病(Alzheimer’s disease,AD)的主要病理特征。Aβ在患者脑内的积聚由多种因素诱导,其中血脑屏障(blood-brain barrier,BBB)对于Aβ在脑内与血液之间的转运发挥关键作用,而这一转运作用是通过BBB上Aβ受体介导的。在AD患者脑内可检测到Aβ转运及相关受体表达的异常,与脑内Aβ含量的异常升高有关。对BBB结构与功能、Aβ转运相关受体的表达及其转运机制进行了综述,并对可能的脑内Aβ跨BBB清除策略进行了总结。Amyloid beta-peptides （ Aβ） is the key pathological feature of Alzheimer’s Disease （AD）. Various factors contrib-ute to the accumulations of Aβ in the brains of patients. Among them, blood-brain barrier （ BBB） plays a crucial role in trans-porting Aβ between the brain and the bloodstream while this transfer function is mediated by the receptor of Aβon BBB. The abnormality of Aβ transport and related receptor expression can be detected in the brains of patients with AD, resulting in an un-usual increase in Aβlevels unusually increased . This review e-laborates the structure and function of BBB, the transport of Aβand the expression and transport mechanism of the related recep-tor, as well as summarizes the possible clearance strategy of Aβacross the BBB.

关 键 词：Β淀粉样蛋白 阿尔茨海默病 血脑屏障 转运 晚期糖基化终末产物受体 低密度脂蛋白受体相关蛋白 

分 类 号：R-05[医药卫生] R322.81