苦参碱对胆囊癌患者血清及胆囊组织中MMP-7,p-STAT3及E-Cad水平的影响  

Effects of Matrine on MMP-7,p-STAT3 and E-Cad Levels in Serum and Gallbladder Tissues of Patients with Gallbladder Carcinoma

作　　者：张茜 郑琪 陈旭 李钟瑞 焦敏[2] 

机构地区：[1]陕西省肿瘤医院肿瘤科,陕西西安710061 [2]西安交通大学第一附属医院肿瘤科,陕西西安710061

出　　处：《现代生物医学进展》2016年第30期5872-5874,5986,共4页Progress in Modern Biomedicine

基　　金：陕西省科技攻关项目(2006K16-G5(1))

摘　　要：目的:探讨苦参碱对胆囊癌患者血清及胆囊组织中MMP-7,p-STAT3及E-Cad水平的影响。方法:收集我院治疗的60例胆囊癌患者,随机分为实验组和对照组,每组30例,患者均择日行胆囊癌标准根治术,实验组患者者在对照组患者基础上术后给予苦参碱胶囊治疗。观察并比较两组患者血清及胆囊组织中MMP-7,p-STAT3及E-Cad水平的变化情况,以及5年中位生存率。结果:与治疗前相比,治疗后两组患者血清及胆囊组织中MMP-7,p-STAT3及E-Cad水平均下降,差异具有统计学意义(P>0.05);与对照组相比,实验组患者治疗后血清及胆囊组织中MMP-7,p-STAT3及E-Cad水平较低,差异具有统计学意义(P>0.05);实验组患者5年中位生存月高于对照组,差异具有统计学意义(P>0.05)。结论:苦参碱能够降低胆囊癌患者血清及胆囊组织中MMP-7,p-STAT3及E-Cad水平,延长生存时间,对临床具有指导意义。Objective： To investigate the effect of Matrine on the levels ofMMP-7, p-STAT3 and E-Cad in serum and gallbladder tissues of patients with gallbladder carcinoma. Methods： 60 cases with gallbladder carcinoma who were treated in our hospital were selected and randomly divided into the experimental group and the control group, with 30 cases in each group. All the patients were optional for gallbladder carcinoma radical operation, while the patients in the experimental group were added the matrine capsules after the operation. Then the levels of MMP-7, p-STAT3 and E-Cad in the serum and gallbladder tissues in patients and the five-years＇ survival rate were observed and compared. Results： Compared with before treatment, the levels of MMP-7, p-STAT3 and E-Cad in the serum and gallbladder tissues of patients after the operation in the two groups decreased, and the differences were statistically significant （P〉0.05）; Compared with the control group, the levels of MMP-7, p-STAT3 and E-Cad in the serum and gallbladder tissues of patients after the operation in the experimental group were lower, and the differences were statistically significant （P〉0.05）; The five-years＇ survival rate in the experimental group was higher than that of the control group, and the difference was statistically significant （P〉0.05）.Conclusion： Matrine can decrease the levels of MMP-7, p-STAT3 and E-Cad in the serum and gallbladder tissues of patients with gallbladder carcinoma, and prolong the survival time, which could provide a reference for clinical research.

关 键 词：苦参碱 胆囊癌 MMP-7 P-STAT3 E-CAD 

分 类 号：R735.8[医药卫生—肿瘤]