Hippo-TAZ 信号通路在乳腺癌及乳腺癌干细胞中的作用  

Roles of Hippo-TAZ signaling pathway in breast cancer and breast cancer stem cells

作　　者：闫冰[1] 卢颖[1] 张春影[1] 李青[1] 毛俊[1] 李连宏[1] 

机构地区：[1]辽宁省肿瘤干细胞重点实验室,大连医科大学病理与法医学教研室116044

出　　处：《国际肿瘤学杂志》2016年第10期779-782,共4页Journal of International Oncology

基　　金：国家自然科学基金（81272430）

摘　　要：Hippo 信号通路在调节器官生长、组织再生、肿瘤发生、发展中起重要作用，而含有 PDZ 结合模序转录共激活因子（TAZ）是其下游核心转录因子，参与整个信号通路的调控。近年来，研究者发现TAZ 过表达与乳腺癌的发生、发展、预后都有着密切的关系。探讨 Hippo 信号通路中 TAZ 与乳腺癌及乳腺癌干细胞的关系，可为乳腺癌诊断和治疗提供新的思路。Hippo signaling pathway plays an important role in the regulation of organ growth,tissue regeneration,tumor occurrence and development.Transcriptional co-activator with PDZ-binding motif （TAZ）is the downstream transcription factor of Hippo signaling,participates in the regulation of the entire signaling path-way.In recent years,many studies have found that over-expression of TAZ has a close relationship with the oc-currence,development and prognosis of breast cancer.Discussing the relationship of Hippo-TAZ with breast cancer and breast cancer stem cells may provide a new way for breast cancer diagnosis and treatment.

关 键 词：乳腺肿瘤 肿瘤干细胞 HIPPO 信号通路 含有 PDZ 结合模序转录共激活因子 

分 类 号：R737.9[医药卫生—肿瘤]