实验性高脂血症动物模型比较分析  

Analysis on animal models of experimental hyperlipidemia

作　　者：胡慧明[1,2] 朱彦陈[1] 朱巧巧[3] 邵峰[1] 石强[1] 庞敏霞[2] 苏洁[2] 陈素红[4,3] 吕圭源[2] 

机构地区：[1]江西中医药大学,江西南昌330004 [2]浙江中医药大学,浙江杭州310053 [3]温州医科大学,浙江温州325035 [4]浙江工业大学,浙江杭州310014

出　　处：《中国中药杂志》2016年第20期3709-3714,共6页China Journal of Chinese Materia Medica

基　　金：国家“重大新药创制”科技重大专项(2014ZX09301307-013,2011ZX09102-011-07);国家自然科学基金项目(81560637);江西省卫生厅中医药管理局科研基金项目(2014A041);江西省教育厅科研项目(GJJ150862)

摘　　要：高脂血症是诱发脂肪肝、动脉粥样硬化、高血黏、冠心病及脑卒中等病的重要危险因素。近年来,随着高脂血症的发病率逐年升高和低龄化趋势增加及其心脑血管并发症等日益明显。高脂血症的病因病机、预防治疗及降脂新药的研究开发成为了医药学界的研究热点。为了有效寻找高脂血症的发病机制和防治措施及中药治疗药物,选择理想的高脂血症动物模型复制方法、制备适合能展示中药特色优势的动物模型尤为重要。然而高脂血症动物模型的复制成功与否是实验性高脂血症研究的关键之一。理想的高脂血症动物模型应该是与人类疾病接近,在高脂血症发病过程中的生理、生化反应也尽可能与人类相一致,模型复制可重复,且试验操作简单、实验成本相对较低、易于推广;模型复制成功与否直接影响整个实验过程的准确性和结果的可靠性。该文就实验性高脂血症动物模型复制方法的研究进行比较分析,为降血脂中药新药研发者合理有效的选择高脂血症动物模型复制方法提供参考和依据。Hyperlipidemia is a major risk factor for fatty liver,atherosclerosis,hyperviscosily,coronary artery disease and acute myocardial infarction. In recent years,the incidence of hyperlipidemia was gradually increased and showed younger trend. It has been a research hot point to study the etiology and pathogenesis of hyperlipidemia and develop a new drug reduced blood lipid. It is very important to prepare the animal model of hyperlipidemia for displaying the advantage of traditional Chinese medicine characteristic. However,the success of replicating animal model of hyperlipidemia is one of the key of research in experimental hyperlipidemia. The ideal animal model of hyperlipidemia should be similar to human disease,high repeatability,simple and high generalization. It will affect the reliability of the results and the accuracy of the whole experiment process to copy successfully animal models of hyperlipidemia. This review focused on the recent research progress on copying methods of animal models of experimental hyperlipidemia,which will provide reference and basis for the hypolipidemic developers who choose rationally and effectively replication methods of hyperlipidemia animal models.

关 键 词：高脂血症 动物模型 复制方法 

分 类 号：R-332[医药卫生] R259