IGFBP基因与胰腺癌相关性的研究进展  

Research Progress of Relationship Between IGFBP Gene and Pancreatic Cancer

作　　者：谭志辉[1] 张先林[1] TAN Zhi-hui ZHANG Xian-lin(Department of General Surgery of Renhe Hospital, Three Gorges University, Yichang 443002, Hubei Province, Chin)

机构地区：[1]三峡大学仁和医院普外科,湖北宜昌443002

出　　处：《中国普外基础与临床杂志》2016年第10期1285-1288,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨胰岛素样生长因子结合蛋白(IGFBP)基因与胰腺癌的相关性。方法复习近年相关的国内外文献,从胰腺癌的相关基因、IGFBP相关的肿瘤及IGFBP与胰腺癌相关性的研究等方面总结前人研究成果。结果大多数研究提示IGFBP能通过IGF依赖通路抑制肿瘤细胞的功能,但目前对IGFBP基因缺失或突变以及调控机理尚不清楚。结论 IGFBP与肿瘤密切相关,但其对胰腺癌的具体影响及其机理尚无定论,要想通过内源性的IGFBP基因水平改变来影响细胞的分化程度、调控肿瘤的生长和转移概率,还需要进一步的研究。Objective To investigate the relationship between insulin-like growth factor binding protein （IGFBP） gene with pancreatic cancer. Methods The relevant literatures at home and abroad in recent years were reviewed. From the pancreatic cancer related genes, IGFBP related tumors and the correlation between IGFBP and pancreatic cancer research and other aspects of the previous research results were summaried. Results Most of the studies suggested that IGFBP could inhibit the function of tumor cells through the IGF dependent pathway, but the deletion or mutation of IGFBP gene and its regulation mechanism are still unclear. Conclusion IGFBP is closely related to the tumor, but its specific effects and mechanism of pancreatic cancer has not been settled. In order to affect the degree of cell differentiation, regulation of tumor growth and metastasis probability through the change of endogenous IGFBP gene level, the further studie is needed.

关 键 词：胰岛素样生长因子结合蛋白 胰腺癌 肿瘤 

分 类 号：R735.9[医药卫生—肿瘤]