血小板计数对宫颈癌新辅助化疗疗效的预测价值  

Predictive value of neoadjuvant chemotherapy effect in cervical cancer patients by platelet counts

作　　者：石红[1] 刘佳华[1] 孙阳[1] 高玉玲[1] 陈政[1] 

机构地区：[1]福建医科大学省立临床医学院福建省立医院妇产科,福州350001

出　　处：《福建医药杂志》2016年第5期81-84,共4页Fujian Medical Journal

摘　　要：目的探讨血小板计数水平预测子宫颈癌新辅助化疗疗效的价值。方法回顾分析2011年1月至2015年12月就诊本院妇产科的宫颈癌患者267例,手术前行新辅助化疗1~3个疗程,化疗前检测患者血小板计数水平,化疗结束后3周评价化疗疗效。结果非鳞癌患者的血小板计数水平明显高于鳞癌患者（P〈0.05）;新辅助化疗无效组患者血小板计数水平明显高于有效组（P〈0.05）,子宫颈癌患者血小板计数水平与新辅助化疗疗效呈负相关;新辅助化疗临床总有效率为79.8%（213/267）;血小板水平≤300×10^9/L组的新辅助化疗有效率为85.3%（122/143）高于血小板水平〉300×10^9/L组的73.4%（91/124）（P〈0.05）。结论血小板计数水平对预测子宫颈癌新辅助化疗的效果有一定临床价值。Objective To investigate the predictive value of neoadjuvant chemotherapy（NACT）effect in cervical cancer patients by the platelet counts.Methods A total of 267 cervical cancer patients in Fujian Province Hospital from Janugry,2011 to December,2015 were treated with 1-3cycles of neoadjuvant chemotherapy and evaluated the therapeutic effects three weeks later after treatment completed.The platelet counts were detected before chemotherapy.Results The platelet counts in nonsquamous carcinoma group were significantly higher than that in squamous carcinoma group（P〈0.05）.The platelet counts in ineffective group were significantly higher than that in effective group;There was negative correlation between the platelet counts and NACT effect.The effective rate of NACT was 79.8%（213/267）;The effective rate of PLT≤250×10^9/L group was 85.3%（122/143）,higher than 73.4%（91/124）of PLT250×10^9/L group（P〈0.05）.Conclusion Platelet counts can predict cervical cancer NACT effect.

关 键 词：宫颈癌 血小板计数 新辅助化疗 

分 类 号：R737.33[医药卫生—肿瘤]