生长抑素与前列地尔联合治疗对高脂血性急性胰腺炎患者血脂、炎性因子的影响  

The influence of co-administration of somatostatin and alprostadil on the level of serum lipid and inflammation factor in the patients with acute pancreatitis

作　　者：王放[1] 朱芳丽[1] 王刚[1] 韩俊岭[1] 

机构地区：[1]秦皇岛市第一医院消化内科,河北秦皇岛066000

出　　处：《临床和实验医学杂志》2016年第20期1996-1999,共4页Journal of Clinical and Experimental Medicine

基　　金：秦皇岛市2011年科学技术研究与发展计划(编号201101A257)

摘　　要：目的探讨生长抑素与前列地尔联合治疗对于高脂血性急性胰腺炎患者体内血脂和炎性因子水平的影响。方法回顾性分析2011年6月至2014年6月进行治疗的64例高脂血性急性胰腺炎患者的临床资料。随机将其分为实验组(采用生长抑素与前列地尔联合用药)和对照组(仅采用生长抑素治疗),各32例。观察两组患者的临床疗效和腹痛、腹胀等基本临床症状,以及比较两组患者治疗前后血清中炎性因子[白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)和超敏C反应蛋白(hs-CRP)]水平和血脂水平。结果实验组患者的治疗有效率显著高于对照组(P<0.05),且实验组患者的基本症状缓解时间也短于对照组(P<0.05);两组患者治疗前各项生理指标均无显著性差异(P>0.05),但治疗后实验组患者的炎性因子水平较对照组降低的更明显(P<0.05),治疗后实验组患者体内总甘油三酯量较对照组降低更明显,高密度脂蛋白胆固醇水平升高更明显(P<0.05)。结论生长抑素和前列地尔联合治疗可以显著降低高脂血性急性胰腺炎患者体内血脂和炎性因子水平,提高治疗有效率。Objective To investigate the influence of co - administration of somatostatin and alprostadil on the level of serum lipid and inflammation factor in the patients with acute pancreatitis. Methods Clinical data of 64 patients with acute pancreatitis from Jun 2011 to Jun 2014 were retrospectively analyzed. These 64 patients were randomly divided into the control group （somatostatin treatment） and the experimental group （ co - administration of somatostatin and alprostadil）, 32 cases in each group. Observation factors included treatment effectiveness and the time to improve clinical symptoms including abdominal pain and distension. On the basis of that, levels of serum lipid （ TC, TG, HDL, LDL） and inflammation factor （ TNF - α, IL - 6, hs - CRP） were compared before and after treatment in patients. Results Treatment effectiveness of patients in the experimental group was significantly higher than that in the control group （ P 〈 0.05 ）. And the time to improve clinical symptoms for experimental group was significantly shorter than that in the control group （ P 〈 0.05 ）. There was no significant difference in the physiological index between the two groups before treatment （ P 〉 0.05 ）. However, after treatment experimental group had a lower level of inflammation factor and TG （ P 〈 0. 05 ）, meanwhile, a higher level of HDL than those in the control group （ P 〈 0.05 ）. Conclusion Co - administration of somatostatin and alprostadil can effectively lower the level of serum lipid and inflammation factor in the patients with acute pancreatitis, improve the treatment efficiency.

关 键 词：高脂血性急性胰腺炎 生长抑素 前列地尔 炎性因子 血脂 

分 类 号：R576[医药卫生—消化系统]