老年非手术食管鳞癌患者同期放化疗的疗效  

Efficacy of concurrent chemoradiotherapy for elderly patients with esophageal squamous cell carcinoma without surgery

作　　者：胡莉钧[1] 于静萍[1] 倪新初[1] 王坚[1] 聂斌[1] 李毅[1] 李栋庆[1] 孙志强[1] 孟庆红[1] 孙苏平[1] 

机构地区：[1]南京医科大学附属常州第二人民医院放疗科,江苏省213003

出　　处：《江苏医药》2016年第19期2088-2091,共4页Jiangsu Medical Journal

基　　金：江苏省卫生厅指导性科研项目(Z201220);常州市卫生局重大项目(ZD201105);常州市科技支撑社会发展项目(CE20125021)

摘　　要：目的观察紫杉醇联合顺铂方案的同期放化疗对老年非手术食管鳞癌患者的临床疗效。方法非手术治疗的老年食管鳞癌患者92例分为同期放化疗组(CCRT组,46例)和单纯放疗组(RT组,46例),比较两组有效率、中位生存期、中位无进展生存期和不良反应发生率。结果与RT组比较,CCRT组有效率高(91.3%vs.73.9%)(P<0.05),中位生存期长(33个月vs.21个月)(P<0.05),中位无进展生存期长(28个月vs.14个月)(P<0.05),但≥3级骨髓抑制发生率高(43.5%vs.4.4%)(P<0.01),≥2级放射性食管炎发生率高(58.7%vs.30.4%)(P<0.01)。结论同期放化疗能够提高老年非手术食管鳞癌患者近期疗效和长期生存率,但不良反应也相应增加。Objective To study the efficacy of concurrent chemoradiotherapy with paclitaxel and cisplatin for elderly patients with esophageal squamous cell carcinoma without surgery .Methods Ninety-two elderly patients with inoperable esophageal squamous cancer were treated with concurrent chemoradiotherapy（group CCRT ,46 cases） or radiotherapy alone（group RT ,46 cases） .The overall response rate ,median survival time ,median progression-free survival （ PFS ） time and adverse effects were compared between two groups .Results Compared to group RT ,group CCRT had a higher effectiveness rate（91.3% vs .73.9% ）（P〈0 .05） ,longer median survival time（33 months vs . 21 months）（ P〈0 .05 ） and median PFS time （28 months vs .14 months ） （ P〈0 .05 ） ,but higher incidence rate of bone marrow suppression （grade ≥ 3）（43.5% vs .4.4% ）（P〈0 .01） and that of esophagitis（grade≥ 2）（58.7% vs .30.4% ）（P〈0 .01） .Conclusion Concurrent chemoradiotherapy can significantly improve the short-term outcomes and long-term survival in the elderly with inoperable esophageal squamous cancer ,but increases the incidence of toxicities .

关 键 词：食管鳞癌 同期放化疗 紫杉醇 老年 

分 类 号：R735[医药卫生—肿瘤]