缺氧诱导因子-1在急性胰腺炎发生发展中的作用  

Role of hypoxia inducible factor-1 in the development of acute pancreatitis

作　　者：曹成亮[1] 曲凤智 王刚[1] 孙备[1] 

机构地区：[1]哈尔滨医科大学附属第一医院胰胆外科,哈尔滨150001

出　　处：《中华肝胆外科杂志》2016年第10期718-720,共3页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金（81100314,81370565）;黑龙江省新世纪优秀人才培养计划（1253-NCET-017）;哈尔滨医科大学于维汉院士杰出青年基金

摘　　要：胰腺腺泡细胞死亡方式是决定急性胰腺炎（AP）病程及预后的重要因素。AP病情轻重与腺泡坏死呈正相关，与腺泡凋亡呈负相关。细胞的三磷酸腺苷（ATP）含量是调控其死亡方式的关键，在多种病理生理过程中扮演了坏死一凋亡转化开关的角色。低水平ATP可加速细胞坏死，高水平ATP则促进其凋亡。缺氧诱导因子-1（HIF-1）是在缺氧条件下高表达的转录因子，可有效调节细胞能量代谢模式，在细胞死亡及炎症损伤调控中发挥了重要作用。本文对HIF-1在AP中的研究进展做一综述，以期为AP发病机制的深入理解和新的治疗靶点的提出提供参考。Pancreatic acinar cell death modality is a significant factor which determines the course and prognosis of acute pancreatitis （AP）. The severity of AP is positively corre- lated with acinar necrosis, while negatively correlated with aci- nat apoptosis. Adenosine triphosphate （ATP） level is the key to control the manner of death, and acts as a switch during the con- version of necrosis and apoptosis in a variety of pathophysiologi- cal settings： low levels of ATP can accelerate cell necrosis and high levels of ATP might promote apoptosis. Hypoxia inducible factor 1 （HIF-1） is a highly expressed transcription factor in anoxic conditions which can effectively regulate cell energy me- tabolism and play an important role in regulating cell death and inflammatory injury. Therefore, this review aimed to provide a reference about better understanding of the pathogenesis and new therapeutic targets of HIF-1 in AP.

关 键 词：急性胰腺炎 缺氧诱导因子-1 坏死 凋亡 三磷酸腺苷 

分 类 号：R576[医药卫生—消化系统]