帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义  

The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

作　　者：时鹏[1] 屈洪党[1] 李强[1] 陈育华[1] 李倩倩[1] 谢静[1] SHI Peng QU Hong-dang LI Qiang CHEN Yu-hua LI Qian-qian XIE Jing(Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, Chin)

机构地区：[1]蚌埠医学院第一附属医院神经内科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2016年第9期1132-1135,共4页Journal of Bengbu Medical College

基　　金：安徽省教育厅自然科学一般项目(KJ2015B094by)

摘　　要：目的：检测帕金森病（PD）患者血清活化T细胞趋化因子（RANTES）水平及炎症因子白细胞介素（IL）-1β、IL-6、肿瘤坏死因子（TNF）-α的变化,探讨其在PD免疫异常发病机制中的作用。方法：采用ELISA法检测60例PD患者（PD组）和35名健康体检者（对照组）血清RANTES、IL-1β、IL-6、TNF-α水平,采用Hoehn-Yahr、UPDRS量表分别对PD患者进行病情评估,同时对2组年龄、性别、吸烟、饮酒、血糖、血压、血脂差异一般状况进行检查。结果：PD组患者血清RANTES、IL-1β、IL-6和TNF-α水平均显著高于对照组（P〈0.01）;PD 1~5期患者血清RANTES水平差异均有统计学意义（P〈0.05~P〈0.01）,而1~5期患者血清IL-1β、IL-6和TNF-α水平差异均无统计学意义（P〉0.05）;PD患者UPDR评分组间血清RANTES水平轻、中和重度组差异均有统计学意义（P〈0.01）,而IL-1β、IL-6和TNF-α水平轻、中和重度各组间差异均无统计学意义（P〉0.05）,且PD组血清RANTES水平与UPDRS评分呈显著正相关关系（P〈0.01）。结论：PD患者血清RANTES、IL-1β、IL-6、TNF-α水平均较对照组有显著升高,提示炎症因子可能发动并维持了PD的发病进程,可为PD患者早期发现、防治提供优先依据。Objective：To detect the levels of serum activated T cells chemokines （RANTES） and inflammatory cytokines [ including interleukin（IL）-1 β, IL-6 and tumor necrosis factor（TNF）-α ] in Parkinson＇s disease（PD） patients, and explore its roles in abnormal immune pathogenesis of PD. Methods ：The serum levels of RANTES, IL-1 β, IL-6 and TNF-α in 60 PD patients （PD group） and 35 healthy people（ control group） were examined using the ELISA method. The disease of PD patients was evaluated using the UPDRS and Hoehn-Yahr score. The age, sex, smoking, drinking alcohol, blood glucose, blood pressure and blood lipid in two groups were examined. Results：The serum levels of the RANTES, IL-1 β, IL-6 and TNF-α in PD group were significantly higher than those in control group （P 〈 0.01 ）. The differences of the serum RANTES levels in stage 1 to 5 PD patients were statistically significant （ P 〈 0.05 to P 〈 0.01 ）, but for the differences of the serum levels of IL-1 β, IL-6 and TNF-α were not statistically significant（ P 〉 0.05 ）. The differences of the serum RANTES levels between the mild, moderate and severe PD patients identified by the UPDRS were statistically significant （P 〈 0.01 ） ,but for the differences of the levels of IL-1 β,1L-6 and TNF-α were not statistically significant （P 〉 0.05 ）, and the level of RANTES was significantly positive correlation with the UPDRS score （P 〈 0.01 ）. Conclusions：Compared with control group, the levels of RANTES, IL-1 β, IL-6 and TNF-α in PD patients increase, which suggest that the inflammatory cytokines may initiate and sustain the process of pathogenesis of PD, and provide the reference in early finding and treating the PD.

关 键 词：帕金森病 活化T细胞趋化因子 白细胞介素-1Β 白细胞介素-6 肿瘤坏死因子-α 

分 类 号：R742.5[医药卫生—神经病学与精神病学]