宫颈鳞癌中RECK与MMP-9的表达及意义  

Expression and significance of RECK and MMP-9 in cervical squamous cell carcinoma

作　　者：张运彩[1] 赵锦[1] 李胜泽[2] ZHANG Yun-cai ZHAO Jin LI Sheng-ze(Department of Gynecology and Obstetrics, The First People＇s Hospital of Bengbu, Bengbu Anhui 233000 Department of Gynecological Tumor, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China)

机构地区：[1]安徽省蚌埠市第一人民医院妇产科,233000 [2]蚌埠医学院第一附属医院肿瘤妇科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2016年第9期1201-1204,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨宫颈鳞癌中逆转录富含半胱氨酸蛋白(RECK)和基质金属蛋白酶(MMP)-9的表达及意义。方法:应用免疫组织化学法,检测20例正常子宫颈组织及70例子宫颈鳞状细胞癌中RECK和MMP-9的表达。结果:RECK蛋白在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为95.00%和31.43%,差异有统计学意义(P<0.01);有淋巴转移组的阳性率较无淋巴转移组明显降低(P<0.01)。MMP-9在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为25.00%和80.00%,差异亦有统计学意义(P<0.01);MMP-9表达在宫颈鳞癌有淋巴转移组的阳性率较无淋巴转移组明显升高(P<0.01)。RECK及MMP-9在宫颈鳞癌中的表达呈负相关关系(P<0.01)。结论:RECK在宫颈鳞癌中表达减少或缺失可能是通过上调MMP-9的表达从而促进宫颈鳞癌的侵袭与转移,RECK和MMP-9与宫颈鳞癌的浸润转移密切相关。Objective：To investigate the expressions and significance of RECK and matrixmetalloproteinase-9 （MMP-9）in the cervical squamous cell carcinoma. Methods： The expressions of RECK and MMP-9 in 20 cases of normal cervical tissue and 70 cases of cervical squamous cell carcinoma were detected using immune histoehemical staining method. Results：The positive rates of RECK protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 95. 00% and 31. 43% , respectively, the difference of which was statistically significant（P 〈 0.01 ）. Compared with the cervical squamous cell carcinoma patients without lymph node metastasis, the positive rate of RECK in patients with lymph node metastasis significantly decreased（ P 〈 0.01 ）. The positive rates of MMP-9 protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 25.00% and 80. 00% , respectively,the difference of which was statistically significant （P 〈 0. 01 ）. Compared with the cervical squamous cell carcinoma patients without lymph node metastasis, the positive rate of MMP-9 in patients with lymph node metastasis significantly increased （ P 〈 0.01 ）. The expression of RECK in cervical squamous carcinoma was negative correlation with the expression of MMP-9 （ P 〈 0.01 ）. Conclusions ： The decreasing or absent of the RECK expression in cervical squamous carcinoma maybe though upregulate the expression of MMP-9 to promote the infiltration and metastasis of cervical squamous carcinoma. The RECK and MMP-9 are closely related to the infiltration and metastasis.

关 键 词：宫颈肿瘤 逆转录富含半胱氨酸蛋白 基质金属蛋白酶-9 

分 类 号：R737.33[医药卫生—肿瘤]