CD147及相关因子在食管癌中的表达及意义研究  

The expression and significance of CD147 and related factors in esophageal cancer

作　　者：李栋庆[1] 胡莉钧[1] 汪建林[1] 孙志强[1] 孟庆红[1] 李毅[1] 聂斌[1] 倪新初[1] 王坚[1] 孙苏平[1] 于静萍[1] 

机构地区：[1]南京医科大学附属常州市第二人民医院放疗科,江苏常州2130000

出　　处：《癌症进展》2016年第8期741-743,747,共4页Oncology Progress

基　　金：江苏省卫生厅指导性科研项目(Z201220);常州市卫生局重大项目(ZD201105);常州市科技支撑社会发展项目(CE20125021);常州市高层次人才(2016czBJ007);常州市科技局应用基础项目(CZ20159050)

摘　　要：目的探讨食管癌中细胞外基质金属蛋白酶诱导因子(EMMPRIN/CD147)在食管癌血管生成通路中的作用。方法随机抽取41例食管癌患者,其中淋巴结转移17例,应用免疫组化方法检测食管癌病理标本中CD147、血管内皮生长因子(VEGF)、血管内皮细胞生长因子受体2(VEGFR2)的表达及微血管密度(MVD)的计数。结果 41例食管癌肿瘤组织中CD147、VEGF、VEGFR2阳性率分别为83%、54%及71%,明显高于正常组织。CD147、VEGFR2、MVD在淋巴结转移阳性与阴性患者之间存在显著差异(Z=-2.857,P=0.004;Z=-2.018,P=0.044;Z=-4.239,P﹤0.001)。食管造影下食管病变的长度与VEGF、CD147及MVD显著相关(r=0.486,P=0.01;r=0.588,P﹤0.001;r=0.604,P﹤0.001)。CD147与VEGF、VEGFR2、MVD之间均存在显著相关(r=0.976,P﹤0.001;r=0.588,P=0.01;r=0.604,P﹤0.001)。结论 CD147与VEGF、VEGFR2、MVD之间均存在显著相关,与食管病变长度密切相关,提示CD147在食管癌血管生成通路中有重要作用,且可能是通过调控VEGF通路实现的,但尚需进一步研究。Objective To investigate the role of extracellular matrix metalloproteinase inducer （EMMPRIN or CD147） in the angiogenic pathways of esophageal carcinoma. Method A random sample of 41 patients pathologically diagnosed with esophageal cancer was enrolled, 17 cases among which were of lymphatic metastasis. Immunohistochemi-cal assay was used in detecting the expression of CD147, vascular endothelial growth factor （VEGF）, vascular endothelial growth factor receptor 2 （VEGFR2） and the counting of microvascular vascular density （MVD） in pathologic specimens of esophageal carcinoma tissues. Result Among 41 cases of pathologic specimens, the positive rates of CD147, VEGF, and VEGFR2 were 83%, 54%and 71%, respectively, and all were higher than those in the normal issues. CD147, VEG-FR2 and MVD were significantly different between patients with positive and negative lymphatic metastasis （Z=-2.857, P=0.004;Z=-2.018, P=0.044;Z=-4.239, P〈0.001）. The length of esophageal lesion detected by esophagogram was corre-lated with VEGF, CD147 and MVD （r=0.486, P=0.01;r=0.588, P〈0.001 and r=0.604, P〈0.001）. And significant correlation was observed between CD147, and VEGF, VEGFR2 and MVD （r=0.976, P〈0.001 and r=0.001, P=0.01;r = 0.604, P〈 0.001）. Conclusion CD147 is significantly correlated with VEGF, VEGFR2, and MVD, as well as the length of esophageal lesion. This suggests CD147’s important role in the angiogenic pathway of esophageal cancer, which is probably realized through regulating VEGF pathways, and further research is needed.

关 键 词：食管癌 CD147 VEGF VEGFR2 MVD 

分 类 号：R735.1[医药卫生—肿瘤]