CXCL16基因rs2277680多态性与急性脑梗死颈动脉斑块的研究  

Research on Chemokine CXC Ligand 16 Gene rs2277680 Polymorphisms and Carotid Artery Plaque with Acute Cerebral Infarction

作　　者：周元林[1] 陈云[1] 朱敏[1] 朱峰[1] 胡晓飞[1] 郑周[1] 

机构地区：[1]温州医科大学附属台州医院神经内科,317000

出　　处：《医学研究杂志》2016年第10期68-71,共4页Journal of Medical Research

基　　金：浙江省医药卫生科研计划项目(2013KYB289)

摘　　要：目的探讨血清趋化因子CXC配体16(CXCL16)基因rs2277680多态性与急性动脉粥样硬化性脑梗死患者的颈动脉斑块易损性的关系。方法 476例急性动脉粥样硬化性脑梗死患者根据B型超声检查结果分为稳定斑块组(218例)和颈动脉易损斑块组(258例)。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法分析CXCL16基因rs2277680多态性。结果稳定斑块组GA+AA基因型频率为80.3%,易损斑块组GA+AA基因型频率显著为87.6%,两组间的GA+AA基因型频率比较差异有统计学意义(x^2=4.772,P=0.032),表明易损斑块组GA+AA基因型频率显著高于稳定斑块组。A等位基因频率在稳定斑块组为63.3%和易损斑块组为62.2%,两组间的A等位基因频率分布比较,差异无统计学意义(x^2=0.121,P=0.737)。结论 CXCL16基因rs2277680多态性AA+GA基因型与急性动脉粥样硬化性脑梗死患者颈动脉斑块易损性存在着相关性;但A等位基因不是颈动脉斑块易损的遗传易感基因。Objective To investigate the association between the chemokine CXC ligand 16 （CXCL16） gene rs2277680 polymorphisms and instability of carotid plaque in patients with acute atherosclerotic cerebral infarction. Methods According to carotid ultrasound examination , 476 patients were divided into two groups, stable plaque group （n = 218 ） and vulnerable plaque （n = 258）. And pol- ymerase chain reaction - restriction fragment length polymorphism （ PCR - RFLP） was used to detect the rs2277680 polymorphisms in the CXCL16 gene. Results The frequency of the GA ＋ AA genotypes was significantly different in the two groups （80.3% vs 87.6% ,x^2 = 4. 772,P=0. 032）. The frequency of the A allele was also not significantly different in the two groups （63.3% vs 62.2% ,x^2 = 0. 121, P = 0. 737）. Conclusion There is a correlation between the CXCL16 gene rs2277680 polymorphisms and instability of carotid plaque in patients with acute atherosclerotic cerebral infarction. But the A allele was not a genetic susceptibility gene which leaded to plaque rupture.

关 键 词：血清趋化因子CXC16 动脉粥样硬化 脑梗死 多态现象 易损斑块 

分 类 号：R74[医药卫生—神经病学与精神病学]