垂体腺瘤MRI Knosp分级与Ki-67、p53、MMP-9的相关性分析  

The correlation between MRI Knosp classification and Ki-67,p53 and MMP-9 in pituitary adenoma

作　　者：何璐[1] 郭亮[1] 胡春洪[1] 虞正权[2] 惠国祯[2] 

机构地区：[1]苏州大学第一附属医院医学影像科,江苏苏州215006 [2]苏州大学第一附属医院神经外科,江苏苏州215006

出　　处：《中华神经外科疾病研究杂志》2016年第5期410-413,共4页Chinese Journal of Neurosurgical Disease Research

基　　金：国家973基金资助项目(2012CB518106)

摘　　要：目的检测增殖细胞核抗原Ki67(Ki-67)、抑癌基因p53(p53)及基质金属蛋白酶-9(MMP-9)在侵袭性及非侵袭性垂体瘤中的表达变化,探讨它们与Knosp分级的相关性。方法选用垂体瘤179例,根据Knosp分级分为侵袭性组(n=91)和非侵袭性组(n=88),应用免疫组化方法检测标本中Ki-67、p53及MMP-9的表达情况。结果 p53、Ki-67和MMP-9在Knosp分级Ⅲ级以上组中显著增高(P<0.01)。结论 Ki-67、p53和MMP-9表达与Knosp分级呈正相关。Objective The expressions of Ki-67, p53 and MMP-9 in the pituitary adenomas were detected to study the correlation between them and Knosp classification.MethodsOne hundred and seventynine cases of pituitary tumor specimens were divided into two groups by Knosp classification, including ninty one cases of invasive pituitary adenoma and eightyeight cases of noninvasive pituitary adenoma. The expressions of proliferation related Ki-67 antigen （Ki-67）, tumor suppressor gene p53 （p53） and matrix metalloproteinase 9 （MMP-9） were detected by immunohistochemistry. ResultsThe rates of Ki-67, p53 and MMP-9 were higher than those in the groups above Knosp classification Ⅲ （P〈0.01）. ConclusionThere is significant positive correlation between Ki-67, p53, MMP-9 and Knosp classification.

关 键 词：垂体瘤 Knosp分级 增殖细胞核抗原Ki67 抑癌基因P53 基质金属蛋白酶-9 

分 类 号：R736.4[医药卫生—肿瘤]