X线交叉互补修复基因3遗传变异与喉癌风险的相关性  

Association between genetic polymorphism in DNA repair genes XRCC3 and risks of laryngeal carcinoma

作　　者：尼力帕尔.阿力木 王玲玲[1] 张波[1] 阿依恒.曲库尔汗[1] 

机构地区：[1]新疆医科大学第一附属医院耳鼻咽喉科,新疆乌鲁木齐830054

出　　处：《中国耳鼻咽喉头颈外科》2016年第9期511-514,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：新疆自治区自然科学基金资助项目(2013211A098)

摘　　要：目的研究DNA修复基因XRCC3 Thr 241 Met（rs861539）遗传变异与喉癌风险的关系。方法采用Multiplex SNaPshot技术（多重单碱基延伸反应技术）对60例喉癌患者和120名正常人进行基因分型,采用多因素Logistic回归模型计算各基因型携带者喉癌的发病风险,以及与吸烟交互对喉癌发病风险的影响。结果XRCC3 24l Met等位基因增加了喉癌发病风险,与XRCC3 241Thr/Thr基因型携带者相比,至少携带一个241 Met等位基因的个体罹患喉癌的OR为4.27,95%CI为1.49~12.18。结论XRCC3Thr 241 Met单核苷酸多态是喉癌的遗传易感因素。OBJECTIVE To study the association between polymorphism of DNA repair gene XRCC3Thr241 Met and the risks of developing laryngeal carcinoma.METHODS Sixty patients with laryngeal carcinoma and 120 cancer-free controls were genotyped for the polymorphism by Multiplex SNaPshot.The odds ratios（ORs） and 95%confidence intervals（Cls） were calculated using unconditional logistic regression model.RESULTS The XRCC3 241 Met allele increased the risks of developing laryngeal carcinoma.Comparing with subjects having the XRCC3241 Thr/Thr genotype,the subjects at least having one XRCC3 241 Met allele had OR of 4.27 {95%CI 1.49-12.18）.CONCLUSION XRCC3 Thr 241 Met plays an important role in the development of laryngeal carcinoma.

关 键 词：喉肿瘤 DNA修复 变异(遗传学) X线交叉互补修复基因3 

分 类 号：R739.65[医药卫生—肿瘤]