幽门螺旋杆菌感染对帕金森病的影响  

Effect of Helicobacter Pylori on Parkinson's Disease

作　　者：林菲菲[1,2] 黄建平[1,2] 朱文宗[1,2] 支英豪[1,2] 金永喜[1,2] 

机构地区：[1]浙江中医药大学第三临床医学院,25000 [2]浙江中医药大学附属温州市中医院,325000

出　　处：《中国临床神经科学》2016年第5期562-567,共6页Chinese Journal of Clinical Neurosciences

基　　金：浙江省自然科学基金项目(编号:LY14H280002)

摘　　要：幽门螺旋杆菌是消化系统常见的致病菌,通常与消化性溃疡相关。然而,近来的研究显示幽门螺旋杆菌感染与很多疾病相关。虽然机制尚不明确,但研究指出幽门螺旋杆菌能抑制许多药物在胃肠道的吸收。研究发现,幽门螺旋杆菌感染在帕金森病(PD)患者中患病率较高,继而影响左旋多巴的吸收导致患者症状波动明显。对幽门螺旋杆菌感染的PD患者使用抗生素进行幽门螺旋杆菌根除治疗能增加左旋多巴的吸收,减少患者症状波动。Helicobacter pylori（HP） is a common infection of the gastrointestinal system that is usually related to peptic ulcers. However, recent studies have revealed the relationships between HP and many other diseases. Although the exact mechanism is unknown, HP can prevent the absorption of certain drugs from the gastrointestinal tract. A high prevalence of HP has been found in patients with Parkinson＇s disease（PD）, and these bacterium cause motor fluctuations by affecting the absorption of levodopa. Eradicating HP from patients with PD by applying antibiotic treatment will increase the absorption of levodopa and decrease their motor fluctuations.

关 键 词：帕金森病 幽门螺旋杆菌 左旋多巴 症状波动 

分 类 号：R742.5[医药卫生—神经病学与精神病学]