复方聚乙二醇电解质散联合心理干预治疗功能性便秘临床疗效观察  

Effect of polyethylene glycol-electrolyte combined with psychological intervention on functional constipation

作　　者：崔曼莉[1] 张超[1] 张明鑫[1] 王景杰[1] 

机构地区：[1]第四军医大学唐都医院消化内科,西安710038

出　　处：《山西医科大学学报》2016年第10期918-922,共5页Journal of Shanxi Medical University

摘　　要：目的探讨聚乙二醇电解质散(polyethylene glycol-electrolyte,PEG)联合心理干预(psychological intervention,PI)治疗功能性便秘的疗效。方法将60名功能性便秘患者随机分为两组,共观察8周。对照组(PEG组)予PEG口服,治疗组(PEG+PI组)口服药物同时联合PI治疗。所有患者采用粪便Bristol评分(Bristol stool scale,BSC)和便秘患者症状自评量表(patient assessment of constipation symptoms,PAC-SYM)全面评估便秘程度,便秘患者生活质量自评问卷(patient assessment of constipation quality of questionnaire,PAC-QOL)评价患者日常生活质量,Zung焦虑自评量表(self-rating anxiety scale,SAS)和抑郁自评量表(self-rating depression scale,SDS)进行心理状态测评,分别于0周、2周、4周和8周进行评分,分析对比两种治疗方式对上述指标的影响。结果两组患者的基线特征如年龄、性别、病程、婚姻状态、收入、睡眠以及BSC、PAC-SYM、PAC-QOL、SAS和SDS评分无明显差异。随着干预时间的增加,两组患者各评分均呈显著下降的趋势(P<0.01);PEG+PI组患者各评分较PEG组下降更明显,于第4周开始出现统计学差异(P<0.01);两组患者均无严重副反应。结论复方聚乙二醇电解质散联合心理干预治疗不仅显著改善便秘症状,还可以纠正患者的焦虑抑郁,患者生活质量较前大幅提高,值得推广。Objective To explore the effect of polyethylene glycol-electrolyte（ PEG） combined with psychological intervention（ PI） on functional constipation. Methods Sixty patients with functional constipation were randomly divided into two groups： PEG group and PEG ＋ PI group. The patients in PEG group were treated with only PEG for 8 weeks,while patients were given PI therapy and PEG oral administration in PEG ＋ PI group. All patients were evaluated by Bristol stool scale（ BSC）,patient assessment of constipation symptoms（ PAC-SYM）,and patient assessment of constipation quality of questionnaire（ PAC-QOL） for the degree of constipation and quality of life. And Zung self-rating anxiety scale（ SAS） and self-rating depression scale（ SDS） were used to evaluate the mental state. All the scores were assessed at 0,2,4,and 8 week. Results The baseline characteristics such as age,sex,disease duration,marital status,income,sleep,BSC,PAC-SYM,PAC-QOL,SAS and SDS scores showed no significant difference between two groups. With the increasing of intervention time,BSC,PAC-SYM,PAC-QOL,SAS and SDS scores in both two groups showed significant downward trend（ P〈0. 01）. All the scores in PEG ＋ PI group decreased more significantly than that in PEG group,and began to appear significant difference at 4 week（ P〈0. 01）. No serious side effects were observed in two groups. Conclusion PEG combined with PI not only significantly relieve the symptoms of constipation,but also have an effect on anxiety and depression status,which can improve the patient＇s quality of life and worth promoting in clinics.

关 键 词：功能性便秘 复方聚乙二醇电解质散 心理干预 

分 类 号：R574.6[医药卫生—消化系统]