粉红丝带引发的思考--Wnt信号通路在乳腺发育与乳腺癌变中的角色  

Mammary development and breast cancer: A Wnt prospective

作　　者：俞清[1] 曾艺[1] YU Qing ZENG Yi(State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

机构地区：[1]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,细胞生物学国家重点实验室,上海200031

出　　处：《科技导报》2016年第20期5-13,共9页Science & Technology Review

摘　　要：Wnt信号转导通路是参与乳腺发育和肿瘤形成的重要机制。本文综述了Wnt信号转导通路调控乳腺发育和干细胞稳态研究的进展,讨论了Wnt信号转导中成员分子在乳腺癌形成中的角色。The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. This paper reviews the current knowledge of how the pathway regulates the stem ceils and the normal development of the mammary gland, and how its various components contribute to the breast carcinoma pathology.

关 键 词：WNT信号 乳腺发育 干细胞 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]