牙周炎患者基础治疗前后龈沟液中IL-35浓度变化的研究  

Changes of IL-35 levels in gingival crevicular fluid before and after basic periodontal treatment in periodontitis patients

作　　者：麻婷婷[1] 王丽[1] 贾树芳 段立荣[1] MA Ting-ting WANG Li JIA Shu-fang DUAN Li-rong(Department of Periodontology,The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属口腔医院牙周病科,黑龙江哈尔滨150001

出　　处：《牙体牙髓牙周病学杂志》2016年第10期617-619,共3页Chinese Journal of Conservative Dentistry

摘　　要：目的:观察牙周炎患者龈沟液(GCF)中的白细胞介素-35(IL-35)浓度与临床指标的相关性。方法:纳入慢性牙周炎患者30人,并分为轻、中、重度3组(n=10);分别于基础治疗前和治疗后1个月于同一位点采集GCF,并记录出血指数(BI)、探诊深度(PD)、临床附着丧失程度(CAL)。用ELISA法分别检测治疗前、后各组GCF中IL-35的浓度变化并进行统计分析。结果:牙周基础治疗1个月后,轻、中、重度3组牙周炎患者GCF中IL-35浓度、BI和重度组的PD、CAL均较其治疗前明显降低(P<0.05);其中以中、重度组的降低程度更显著。相关分析结果显示,基础治疗前后各组GCF中的IL-35浓度与其各临床指标均无显著相关性(P>0.05)。结论:牙周基础治疗能改善牙周炎患者的临床指标,降低龈沟液中的IL-35水平;提示IL-35可能参与了牙周炎的疾病进程。AIM： To study the correlation between IL-35 levels in gingival crevicular fluid （GCF） and clinical index in patients with periodontitis. METHODS： 30 periodontitis patients were divided into mild, moderate and severe chronic periodontitis groups （ n = 10 ） based on clinical index. GCF was collected at the same site before and 1 month after periodontal treatment. Bleeding index （ BI）, probing depth （PD） and clinical attachment loss （CAL） were measured and recorded. ELISA was used to determine the concentration IL-35 in GCF. RESULTS： 1 month after treatment, IL-35 levels and clinical indices were significantly lower than those before treatment in all the 3 groups（P 〈 0.05 ）. Furthermore, the decreasing effect was more significant in moderate and severe groups than in mild group （ P 〈 0.05 ）. Correlation analysis showed no significant correlation between the change of IL-35 levels and the change of clinical indices（ P 〉 0.05 ）. CONCLUSION： IL-35 might be involved in the process of periodontitis.

关 键 词：牙周炎 牙周基础治疗 白细胞介素-35(IL-35) 龈沟液(GCF) 

分 类 号：R781.4[医药卫生—口腔医学]