蛋白质基因组学的建立及其在转化医学中的应用  

Establishment of Proteogenomics and its Application in Translational Medical Research

作　　者：胡旭[1] 曹新[1] 魏钦俊[1] 

机构地区：[1]南京医科大学基础医学院生物技术系,江苏南京211166

出　　处：《生物技术通讯》2016年第5期699-704,共6页Letters in Biotechnology

基　　金：国家自然科学基金面上项目(81172142)

摘　　要：蛋白质基因组学是蛋白质组学和基因组学研究的交叉领域,能够对疾病模型提供基因和蛋白质水平的双重验证。近年来,蛋白质基因组学已在病原微生物定性、疾病生物标志物探索、肿瘤发生发展机制揭示、神经退行性疾病发生机制探究以及内毒素易感选择性分析等多个医学研究领域得到应用并快速发展。随着医学研究的深入,以蛋白质基因组学为代表的多组学联合手段还将会被应用到医学研究的更多方面。本文系统介绍了蛋白质基因组学的现有技术路线,并展望其研究优势和应用价值,综述了当前蛋白质基因组学发展最为迅速的医学研究应用领域进展,进一步阐述了蛋白质基因组学在医学应用领域未来可能的发展方向。Proteogenomics is an interdisciplinary research field of proteomics and genomics, which is able to pro-vide authentication on the disease model in both gene and protein levels. And it has been used in a variety ofmedical research areas, such as quantifying particular pathogenic microorganisms, exploring disease biomarkers, re-vealing metabolisms of cancer generation and development, researching metabolisms of neurodegenerative diseasesand analyzing endotoxin selectively susceptibility. In the future, multi- omics combination led by proteogenomicswill be applied to more aspects of medical research. This article has systematically introduced the conventionalroute of proteogenomics and researches of great strength and value, then reviews most rapid development of cur-rent proteogenomics applications in medical research, and describes the probable directions of the proteogenomicsdevelopment in medical applications.

关 键 词：蛋白质基因组学 质谱 肿瘤 转化医学 

分 类 号：Q51[生物学—生物化学] Q811.4