乳腺癌干细胞的研究现状  

Research Status of Breast Cancer Stem Cells

作　　者：贾晓蒙[1] 王琳[2] 孙银萍 叶棋浓[4] 吕朝晖[1] 

机构地区：[1]解放军总医院内分泌科,北京100853 [2]解放军316医院内科,北京100093 [3]中央军委后勤保障部北京老干部服务管理局门诊部,北京100071 [4]军事医学科学院生物工程研究所,北京100850

出　　处：《生物技术通讯》2016年第5期720-723,共4页Letters in Biotechnology

基　　金：国家自然科学基金(81372161;31470773;81272231)

摘　　要：乳腺癌干细胞是乳腺癌中极少数具有自我更新、多向分化潜能和高度致瘤性的细胞亚群,与乳腺癌的发生、发展、复发、转移密切相关。目前为止,多数研究阐述了乳腺癌干细胞的分子表型、分子亚型及相关的细胞信号转导通路及治疗意义,现就以上方面研究做简要综述。Breast cancer stem cells are a small subpopulation of cancer cells having the ability of self-renewingand multi-lineage differentiation, which have also been termed as ＂tumor-initiating cells＂. Many studies suggestthat breast cancer stem cells are closely related to tumor evolution, progression, recurrence and metastasis. So far,some researches elaborate the phenotype, molecular subtypes, molecular pathways and therapeutic implication. Thisarticle makes a summary on mentioned aspects above.

关 键 词：乳腺癌 干细胞 信号通路 分子表型 综述 

分 类 号：R737.9[医药卫生—肿瘤]