交感神经皮肤反应和短潜伏期体感诱发电位测定在卒中后抑郁患者早期诊断中的价值  

Role of sympathetic skin response and short latency somatosensory evoked potential in early diagnosis of patients with post-stroke depression

作　　者：刘卓[1] 智屹忠[1] 徐运[1] 金佳丽[1] 常蕾蕾[1] LIU Zhuo ZHI Yizhong XU Yun et al(Department of Neurology, Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, CHINA)

机构地区：[1]南京大学医学院附属鼓楼医院神经内科,江苏省210008

出　　处：《江苏医药》2016年第20期2200-2202,共3页Jiangsu Medical Journal

基　　金：国家自然科学青年基金(81200876);江苏省卫生计生委面上科研课题(H201538)

摘　　要：目的探讨交感神经皮肤反应(SSR)和短潜伏期体感诱发电位(SLSEP)测定在卒中后抑郁(PSD)患者的早期诊断价值。方法 PSD患者57例,均为首次发病;排除既往有周围神经病、精神病史和检查不合作者。汉密尔顿抑郁量表(HAMD)评分>18分。其中,轻中度PSD组(18分<HAMD评分≤24分)36例,重度PSD组(HAMD评分>24分)21例。50例健康体检者为对照组。测定并比较三组SSR和上、下肢SLSEP。结果与对照组比较,重度和轻中度PSD组的SSR潜伏期延长,波幅降低(P<0.05),SLSEP潜伏期延长(P<0.05);重度PSD组变化大于轻中度PSD组(P<0.05)。结论 PSD患者的SSR和SLSEP均明显异常;其异常程度与抑郁严重程度相关,可作为PSD患者的诊断参考指标。Objective To investigate the value of sympathetic skin response （SSR） and short latency somatosensory evoked potential （SLSEP） in early diagnosis of the patients with post‐stroke depression（PSD） .Methods The SSR and SLSEP were detected in 57 patients with PSD ,who had Hamilton depression rating scale （HAMD ） score 〉 18 points without peripheral neuropathy and mental sickness ,and were divided into two groups of A （HAMD score 〉24 points） and B（18 points〈HAMD score ≤ 24 points ） .Fifty healthy people were taken as the controls （group C ） .Results Compared to group C ,groups of A and B showed longer latency and lower amplitude of SSR （P〈0 .05） and longer latency of SLSEP（P〈0 .05） ,which were more in group A than those in group B（P〈0 .05） .Conclusion The abnormalities of SSR and SLSEP exist in the patients with PSD ,which are associated with the illness of depression and may be taken as the reference indexes in the diagnosis of PSD .

关 键 词：抑郁 卒中 交感神经皮肤反应 短潜伏期体感诱发电位 

分 类 号：R741[医药卫生—神经病学与精神病学]