动态增强磁共振成像在评估急性白血病骨髓浸润中的诊断价值  

Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Evaluating Diffuse Tumor Infiltration of Bone Marrow in Patients with Acute Leukemia

作　　者：刘德浩[1] 汪敬群[1] 吴小强[1] 庄雄杰[1] 周勇[2] 

机构地区：[1]厦门大学附属第一医院放射科,福建厦门361000 [2]厦门大学附属第一医院血液科,福建厦门361000

出　　处：《中国实验血液学杂志》2016年第5期1365-1368,共4页Journal of Experimental Hematology

摘　　要：目的:分析动态增强磁共振成像(MRI)在评估急性白血病(AL)骨髓浸润中的诊断价值。方法:选取2010年1月-2016年2月期间我院收治的80例AL患者(患者组)及100例健康者(对照组),所有受试者均接受常规M RI及增强扫描M RI(CEM RI),比较两组的髂骨及椎体的最大强化率(Emax)及强化斜率(Slope),分析AL患者Emax及Slope与原始细胞百分比(protocells%)的相关性。结果:AL患者的腰椎Emax及Slope高于对照组,差异具有统计学意义(P<0.05)。与治疗前相比,CR患者及PR患者的Emax及Slope明显下降(P<0.05)。Protocells%=-0.5632+0.0540Emax+0.0056Slope。AL患者的Emax及Slope与患者的Protocells%存在显著相关性(P<0.05)。结论:增强扫描MRI检查与急性白血病骨髓浸润患者的病理学检查结果及治疗效果具有一定的相关性。Objective：To analyze the value of dynamic contrast-enhanced magnetic resonance imaging（CEMRI） for evaluating diffuse tumor infiltration of bone marrow in patients with acute leukemia（AL）.Methods：From January2010 to February 2016,80 ALpatients admitted in our hospital were chosen as AL patient group,100 healthy people were chosen as control group,and all subjects were diagnosed with MRI and CEMRI.The Emax and Slope of ilium and vertebra lumbalis were compared between AI patient and control groups.The relation of Emax and Slope with protocells%was analyzed.Results：The Emax and Slope of AL patients were significantly higher than those of control group（P〈0.05）.After treatment,the Emax and Slope of CR/PR patients decreased significantly（P〈0.05）.Multiple regression analysis showed that the protocells%=-0.5632 ＋ 0.0540 Emax ＋ 0.0056 Slope.The Emax and Slope of AL patients had significant correlation with Protocells%（P〈0.05）.Conclusion：The results of CEMRI relate with pathological examination and treatment effect.

关 键 词：动态增强磁共振成像 急性白血病 骨髓浸润 

分 类 号：R733.71[医药卫生—肿瘤] R445.2[医药卫生—临床医学]