中性粒细胞CD64阳性指数对白血病患者早期感染的诊断价值  

Diagnostic Value of CD64^+ Index of Neutrophils for Patients with Leukemia Combined with Early Infection

作　　者：郭剑 贾军 车文忠[3] 袁汶[4] 孔丽蕊 

机构地区：[1]青海省第三人民医院检验科,青海西宁810007 [2]青海省红十字医院检验科,青海西宁810000 [3]青海省中医院检验科,青海西宁810000 [4]青海省人民医院检验科,青海西宁810000 [5]四川省郫县中医医院检验科,四川郫县611730

出　　处：《中国实验血液学杂志》2016年第5期1375-1378,共4页Journal of Experimental Hematology

摘　　要：目的:分析中性粒细胞CD64^+指数对白血病患者早期感染的诊断价值。方法:选取2014年6月-2015年6月期间青海省红十字医院收治的100例白血病患者作为研究对象,其中感染者50例,非感染者50例;同一时期来青海省红十字医院院进行健康体检者200例作为对照组,比较降钙素原(PCT)、C-反应蛋白(CRP)、Neu%及中性粒细胞CD64^+指数对300例受试者的灵敏度及特异度,并计算约登指数,比较上述指标的诊断价值。结果:在100例AL患者中,CD64^+指数、Neu%、PCT和CRP 4项指标的灵敏度分别为88.00%、82.00%、74.00%和70.00%,特异度分别为80.00%、78.00%、82.00%和84.00%,约登指数分别为0.68、0.60、0.56和0.54。CD64^+指数诊断价值高于Neu%、PCT和CRP。结论:中性粒细胞CD64^+指数在白血病患者早期感染的诊断中具有一定价值。Objective：To analyze the diagnostic value of CD64 index of neutrophils for patients with leukemia combined with early infection.Methods：From June 2014 to June 2015,100 AL patients admitted in Third People’s Hospital of Qinghai province were chosen as AL group,among them 50 AL patients were in infection group and other 50 patients were in non-infection group;at the same time,200 healthy people were chosen as control group.The sensitivity,specificity and Youden’s index of PCT,CRP,Neu%and CD64＋ index in 300 subjects were calculated,and the diagnostic value of different indicators were compared.Results：In 100 AL patients,the sensitivitys of CD64＋,Neu%,PCT and CRP were respectively 88.00%,82.00%,74.00%and 70.00%;their spesitivitys were respectively80.00%,78.00%,82.00%and 84.00%;their Youden’s indexex of were respectively 0.68,0.60,0.56 and 0.54.Conclusion：CD64＋ index of neutrophils has diagnostic value for patients with leukemia combined with early infection.

关 键 词：白血病 早期感染 中性粒细胞 CD64+阳性指数 

分 类 号：R733.7[医药卫生—肿瘤] R331.142[医药卫生—临床医学]