HBV感染对淋巴瘤患者自体外周血造血干细胞采集及植入的影响  

Effects of Hepatovirus B Infection on the Hematopoietic Stem Cell Collection and Implantment in Lymphoma Patients Received Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation

作　　者：王晓宁[1] 贺鹏程[1] 郭彩利[1] 孙春红[1] 张梅[1] 刘华胜[1] 

机构地区：[1]西安交通大学医学院第一附属医院血液内科,陕西西安710061

出　　处：《中国实验血液学杂志》2016年第5期1397-1403,共7页Journal of Experimental Hematology

摘　　要：目的:探讨淋巴瘤合并HBV感染对自体外周血造血干细胞采集及移植后造血重建的影响。方法:收集2006年1月至2014年10月西安交通大学医学院第一附属医院40例行自体移植的淋巴瘤患者的临床资料进行回顾性分析及随访。40例患者中8例合并有HBV感染,32例未合并HBV感染,对合并HBV感染者给予预防性应用核苷类似物抗乙肝病毒治疗,观察两组患者采集的单个核细胞数及CD34^+细胞数、造血重建和总生存率及疾病无进展生存率间的差异。结果:40例患者的自体外周血造成血干细胞的采集均达标,两组患者采集的单个核细胞数及CD34^+细胞数无显著性统计学差异,8例合并HBV感染的患者在移植中均无HBV的再激活。至随访结束,合并HBV感染患者1年、3年及5年总生存率和疾病无进展生存率分别为100%、85.7%和57.1%及100%,80%和53.3%,未合并HBV感染患者1年、3年及5年总生存率和疾病无进展生存率分别为100%、88.9%,82.1%及90%,90%和90%。结论:HBV感染对自体外周血造血干细胞的采集和植入可能无影响。预防性应用核苷类似物可有效预防HBV再激活,且对自体外周血造血干细胞采集及植入无影响。Objective：To investigate the effect of hepatovirus B（HBV） infection on the hematopoietic stem cell collection and implantment in lymphoma patients received autologous peripheral hematopoietic blood stem cells transplantation.Methods：Clinical data of 40 lymphoma patients who received autologous peripheral hematopoietic blood stem cell transplantation between January 2006 and October 2014 was analyzed retrospectively.Among 40 patients with lymphoma 8 patients combined with HBV infection were prophylacticly given nucleoside analogues and 32 patients without HBV infection.The counts of mononuclear cells（MNC） and CD34 positive cells were collected and the hematopoietic reconstitution as well as overall survival rates and progress-free survival rates were detected and counted between patients with or without HBV infection.Results：The counts of MNC and CD34 positive cells in all patients were standard,and there was no significant difference between patients with or without HBV infection.HBV wasn’t reactivated among the 8 patients with HBV infection.The 1,3 and 5 years’ overall survival rates and progress-free survival rates of patients with HBV infection were 100%,85.7%,57.1%and 100%,80%,53%,respectively and the1,3 and 5 years’ overall survival rates and progress-free survival rates of patients without HBV infection were 100%,88.9%,82.1%and 90%,90%,90%,respectively.Conclusion：HBV infection may have no effect on the collection of stem cells and hematopoietic reconstitution.Prophylactic use of nucleoside analogues can effectively prevent the hepatitis B virus reactivation,moreover had no effect on the collection and hematopoietic reconstitution.

关 键 词：淋巴瘤 自体外周血造血干细胞移植 HBV感染 

分 类 号：R733.1[医药卫生—肿瘤]