S100A6 mRNA在多发性骨髓瘤病人中的表达及意义  

Expression Level of S100A6 mRNA in MM and Its Clinical Significance

作　　者：包红雨[1] 王建宁[1] 孟庆齐[1] 宋敏[1] 付行才[1] 侯艳秋[1] 张柳波[1] 蒋苏豫[1] 

机构地区：[1]南京医科大学第二附属医院血液科,江苏南京210000

出　　处：《中国实验血液学杂志》2016年第5期1466-1469,共4页Journal of Experimental Hematology

基　　金：南京医科大学第二附属医院青年科技启动基金项目(编号QN201001);南京医科大学科技发展基金重点项目(编号2012NJMU089);江苏省"六大人才高峰"第11批次高层人才选拔培养资助项目(编号WSN-019)

摘　　要：目的:探讨钙结合蛋白A6(S100A6)mRNA在多发性骨髓瘤(MM)病人中的表达及临床意义。方法:应用Real time PCR测定骨髓单个核细胞S100A6 mRNA表达,并应用统计学法分析相关结果,比较MM患者与正常人之间以及不同分期患者之间S100A6 mRNA表达差异,以及S100A6高表达组和S100A6低表达组化疗效果及髓外转移差别。结果:MM患者S100A6 mRNA表达明显高于正常对照者(P<0.05),Ⅲ期患者表达明显高于Ⅰ/Ⅱ期患者(P<0.05),Ⅰ、Ⅱ期患者间无明显差别(P>0.05),S100A6 mRNA高表达者预后较低表达者预后差(P<0.05),髓外转移发生率较低表达者明显升高(P<0.05)。结论:S100A6 mRNA在多发性骨髓瘤发病中有一定意义,有望作为骨髓瘤患者不同分期、髓外转移及评估病人预后的提示指标。Objective：To investigate the expression level of S100A6 mRNA in MM and to its clinical significance,and to evaluate its significance.Methods：The expression level of S100A6 mRNA in MM patients was determined by real time quantitative PCR（RQ-PCR）,and its relationship with the clinical features and outcomes of patients was analyzed by statistic method.Results：S100A6 mRNA was detected in 20 MM patients.Compared with normal persons,the S100A6 mRNA expression in MM patients was higher.In different groups,the S100A6 mRNA expression in MM patients of 3 stages was higer than that in patients of 1 and 2 stages.MM patients with higher S100A6 mRNA expression had poor prognosis and higer extramedullary metastasis rate.Conclusion：The high expression of S100A6 mRNA is associated with poor prognosis and may be a prognostic molecular marker of MM.

关 键 词：钙结合蛋白A6 多发性骨髓瘤 髓外转移 

分 类 号：R733.3[医药卫生—肿瘤]