1817例女性人乳头瘤病毒感染现状分析  

Analysis of 1817 cases of papilloma virus infection in women

作　　者：史梅[1] 张丽蓉[1] 许小朋[1] 孙靖[1] 张晓磊[1] 柳楠楠 史伟峰[1] 

机构地区：[1]江苏省常州市第一人民医院检验科,213003

出　　处：《国际检验医学杂志》2016年第20期2862-2863,2866,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨常州地区女性人乳头瘤病毒（HPV）的感染类型、主要亚型及年龄分布等情况。方法采集2015年10月至2016年7月1 718例该院门诊妇科患者宫颈上皮细胞标本,采用PCR-反向点杂交法对其进行28种基因分型的检测。结果 （1）1 718例女性患者,HPV阳性检出率为34.23%。（2）单一型感染率为23.57%（405/1 718）,包括高危型HPV感染率为17.17%（295/1 718）,低危型HPV感染率为5.18%（89/1 718）,疑似高危型HPV感染为1.22%（21/1 718）;多重感染为10.94%（188/1 718）。（3）最常见高危型为HPV52型,阳性率为16.16%（95/588）;低危型感染以HPV61型为主,阳性率为4.08%（24/588）;各年龄组之间HPV阳性率比较,差异无统计学意义（P〉0.05）。61-70岁年龄组的多重感染率与其他年龄组比较,差异有统计学意义（P〈0.05）。结论常州地区女性HPV阳性检出率较高,以单一型感染和高危型感染为主,最常见的高危型为HPV52型,其次为16、58型。不同年龄组HPV感染类型略有差异。Objective To investigate the infection status and genotype distribution of human papillomavirus（HPV）infection in Changzhou district,and to provide a theoretical basis for the prevention,development and clinical diagnosis and treatment of HPV.Methods From October 2015 to July 2016,1 718 cases of female cervical epithelial cells were collected,and 28 kinds of gene typing were detected by PCR-reverse dot blot hybridization.Results The infection rate：1 718 cases of women were collected,the positive HPV infections were 34.23%.The infection types：single infection rate was 23.57%（405/1 718）.The high-risk HPV subtype infections accounted for 17.17%（295/1 718）and the low-risk HPV subtype infections accounted for 5.18%（89/1 718）,suspected high-risk infection was 1.22%（21/1 718）.Multiple infection rate was 10.94%（188/1 718）.HPV52 was the most common infection among high-risk HPV infection,the positive rate was 16.16%（95/588）.HPV61 was the most common infection among lowrisk HPV infection,the positive rate was 4.08%（24/588）.There was no significant difference between age and HPV positive rate.The 61-70 age group had the highest HPV multiple infection rate in all age groups.Conclusion The high HPV infection is observed in Changzhou district,among which single HPV52 infection and the high-risk HPV infection are the most common infections.There is difference in HPV infection among different age groups.

关 键 词：人乳头瘤病毒 宫颈癌 基因型 PCR-反向点杂交 

分 类 号：R737.33[医药卫生—肿瘤]