PCOS不孕患者行新鲜与冷冻周期胚胎移植的妊娠结局比较  

Comparison of pregnancy outcomes between frozen-embryo transfer and fresh-embryo transfer in PCOS patients

作　　者：高婷婷[1] 贺晓[1] 张亨德[1] 陈书强[1] 李博[1] 王晓红[1] 

机构地区：[1]第四军医大学唐都医院妇产科生殖医学中心,西安710038

出　　处：《生殖医学杂志》2016年第11期973-976,共4页Journal of Reproductive Medicine

基　　金："十二五"国家科技支撑计划项目(No:2012BAI32B0)

摘　　要：目的探讨多囊卵巢综合征(PCOS)不孕女性采用IVF-ET助孕治疗中,行冷冻周期和新鲜周期移植胚胎的妊娠结局。方法回顾性分析2010年1月至2014年12月间因单纯PCOS不孕于第四军医大学唐都医院生殖医学中心进行IVF-ET助孕、并行冷冻胚胎移植的患者共389个周期,为PCOS-冷冻周期组;与同期PCOS不孕患者行IVF-ET助孕而移植新鲜胚胎的患者共255个周期,为对照组,比较两组的妊娠结局及新生儿状态。结果 PCOS-冷冻周期组的种植率、临床妊娠率均高于对照组的种植率和临床妊娠率,差异有统计学意义(P<0.05);PCOS-冷冻周期组的异位妊娠率显著低于对照组的异位妊娠率(P<0.05);PCOS-冷冻周期组与对照组的子宫内膜厚度、自然流产率、早产率、多胎率比较,差异无统计学意义(P>0.05)。PCOS-冷冻周期组与对照组的单胎足月儿体重、单胎足月低体重儿比率、单胎足月巨大儿比率、单胎早产儿体重、多胎早产儿体重及多胎足月儿体重比较,均无统计学差异(P>0.05)。结论 PCOS不孕症采用IVF-ET助孕治疗,冷冻周期移植方案比长方案促排卵并新鲜周期移植的PCOS患者有更好的妊娠结局,以及相似的新生儿结局。Objective： To evaluate the pregnancy outcomes between frozen-embryo transfer and fresh-embryo transfer in infertile patients with polycystic ovary syndrome（PCOS）. Methods： The data of the patients with PCOS including 389 frozen-embryo transfer cycles （FET group）and 255 fresh-embryo transfer cycles（control group）in the Assisted Reproduction Center of Tangdu hospital from January 2010 to December 2014 were retrospectively analyzed. The pregnancy outcome and neonatal outcome were compared between the two groups. Results： The implantationrate（44.34% vs. 22. 71%） ,clinical pregnancy（65. 55% vs. 38.82%）inFET group were significantly higher than those in control group（P〈0.05）. The ectopic pregnancy rate（1.57% vs. 16.16%）in FET group was significantly lower than that in control group（P〈0.05）. The endometrial thickness, spontaneous abortion rate, preterm birth rate, multiplet rate, birth weight in full-term singleton, ratio of low birth-weight in full-term singletons,ratio of macrosomia in full-term singleton, birth weight in premature singleton, birth weight in premature multiplets, birth-weight in full term multiplets were not significantly different between two groups（P〉0.05）.Conclusions： Frozen-embryo transfer has better pregnancy outcome and similar neonatal outcome compared with fresh-embryo transfer in PCOS patients.

关 键 词：多囊卵巢综合征 不孕 体外受精-胚胎移植技术 冷冻周期 妊娠结局 

分 类 号：R[医药卫生]