衰老相关分泌表型的研究进展  

The research progress of senescence-associated secretory phenotype

作　　者：郭慧宁[1] 凌霜[1] 刘俊[1] 李玉凤[1] 王淑荣[1] 党延启 陈小淼[1] 许锦文[1] 

机构地区：[1]上海中医药大学穆拉德中药现代化研究中心,上海201203

出　　处：《中国药理学通报》2016年第11期1505-1509,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274130);上海市教委085项目高等教育内涵建设基金项目(No 085ZY1202)

摘　　要：细胞衰老的同时常伴随着衰老相关分泌表型(senescence-associated secretory phenotype,SASP)的产生。SASP由促炎细胞因子、生长因子、趋化因子和基质重塑酶等一系列细胞因子组成,它们可以导致机体慢性低度炎症和疾病,并可以反作用于衰老细胞及其邻近细胞加速它们的衰老进程,并可作为新的细胞衰老效应机制。该文通过对SASP生物学功效、分泌调节、机制、以及与相关疾病关联的探讨,提高我们对SASP的认知,引发我们对SASP相关疾病疗法的思考。When senescence induction is based on DNA damage,senescent cells display a unique phenotype,which has been termed 'senescence-associated secretory phenotype '( SASP).SASP, including proinflammatory cytokines, growth factors,chemokines,matrix remodeling enzymes and other cytokines,may be an important driver of chronic inflammation and therefore may be part of a vicious cycle of inflammation,DNA damage and senescence. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacerbate their regenerative capacity. SASP is associated with many chronic age-related diseases.

关 键 词：细胞衰老 衰老相关分泌表型 SASP 炎症 衰老机制 衰老相关疾病 

分 类 号：R-05[医药卫生] R329.25