小剂量阿糖胞苷阿克拉霉素和粒细胞集落刺激因子联合治疗骨髓增生异常综合征转化急性白血病的临床疗效  

Clinical efficacy of low-dose cytarabine,aclarubicin and granulocyte colony stimulating factor combined therapy for acute leukemia transformed from myelodysplastic syndromes

作　　者：陈炜[1] 张童童[1] 徐燕红[1] 

机构地区：[1]江苏省南通市如东县人民医院血液内科,如东226400

出　　处：《中国肿瘤临床与康复》2016年第10期1193-1195,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨小剂量阿糖胞苷、阿克拉霉素和粒细胞集落刺激因子联合治疗骨髓增生异常综合征(MDS)转化急性白血病的临床疗效。方法选取2005年3月至2014年3月间江苏省南通市如东县人民医院血液内科收治的122例MDS转化的急性白血病患者,采用随机数字表法随机分为观察组和对照组,每组61例。观察组患者采用小剂量阿糖胞苷、阿克拉霉素和粒细胞集落刺激因子联合治疗,对照组患者采用常规化疗治疗,比较两组患者的临床疗效。结果观察组患者治疗的总有效率为90.2%(55/61),显著高于对照组的70.5%(43/61),差异有统计学意义(P<0.05)。观察组患者的不良反应发生率为14.8%(9/61),显著低于对照组的41.0%(25/61),差异有统计学意义(P<0.05)。结论小剂量阿糖胞苷、阿克拉霉素和粒细胞集落刺激因子联合治疗MDS转化的急性白血病的临床疗效较常规化疗治疗好,且具有较高的安全性。Objective To evaluate the clinical efficacy of low-dose cytarabine,doxorubicin aclarubicin and granulocyte colony stimulating factor（ G-CSF） combined therapy in treating acute leukemia transformed from myelodysplastic syndrome（ MDS）. Methods Selected 122 patients with acute leukemia transformed from MDS admitted in Rudong County People＇s Hospital between March 2005 to March 2014. Using random number table,patients were randomly divided into observational group and control group with 61 patients in each group. Patients were given low-dose cytarabine,aclarubicin and G-CSF in the observational group while patients in the control group received conventional chemotherapy treatment. Clinical efficacy was compared between two groups. Results The total effective rate was 90. 2%（ 55 /61） in the observational group which was significantly higher than 70. 5%（ 43 /61） of the control group（ P 〈 0. 05）; incidence of adverse reactions in the observational group was 14. 8%（ 9 /61） which was significantly lower than 41. 0%（ 25 /61） of the control group（ P〈 0. 0）. Conclusion Compared with conventional chemotherapy treatment,combination therapy of low-dose cytarabine,aclarubicin and G-CSF has a high efficacy and safety for acute leukemia transformed from MDS.

关 键 词：骨髓增生异常综合征 白血病 阿糖胞苷 阿克拉霉素 粒细胞集落刺激因子 治疗结果 

分 类 号：R733.7[医药卫生—肿瘤]