螺旋 CT 多层扫描结合99mTC-甲氧异丁基异腈亲肿瘤显像在孤立性肺结节病变诊断中的应用  

Application of multislice CT scan combined with 99mTC -MIBI -SPECT in the diagnosis of isolation pulmonary nodule lesions

作　　者：李莹 谢继承[2] 王琤[3] Li Ying Xie Jicheng Wang Zheng(Department of Radiology, the First People ＂s Hospital of Linhai , Linhai , Zhejiang 317000, China Department of Radiology, Taizhou Hospital Affliated to Wenzhou Medical University, Taizhou, Zhejiang 317000, China Department of Nuclear Medicine, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou , Zhejiang 317000, China)

机构地区：[1]临海市第一人民医院放射科,浙江省临海317000 [2]温州医科大学附属台州医院放射科,浙江省台州317000 [3]温州医科大学附属台州医院核医学科,浙江省台州317000

出　　处：《中国基层医药》2016年第20期3045-3049,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省台州市科技计划项目（14SF03）

摘　　要：目的：探讨螺旋 CT 多层扫描结合99mTC-甲氧异丁基异腈亲肿瘤显像（99mTC-methoxy isobutyl isonitrile injection，MIBI-SPECT）在孤立性肺结节病变诊断中的应用价值。方法选取2014年7月至2015年8月住院治疗的 X 线胸片中出现孤立性肺结节影的患者共60例，对其行螺旋 CT 扫描及99mTC-MIBI-SPECT显像。对比扫描结果与病理检查或手术结果，统计分析得出该方法在鉴别诊断孤立性肺结节中的特异度、灵敏度及准确度。结果单纯螺旋 CT 多层扫描显像的特异度、灵敏度、准确度分别为73．6％、78．2％、79．3％；单纯99mTC-MIBI-SPECT 显像的特异度、灵敏度、准确度分别为82．6％、78．2％、79．3％；螺旋 CT 多层扫描结合99mTC-MIBI-SPECT 显像的特异度、灵敏度、准确度为93．3％、93．2％、93．8％。联合检测准确性明显高于99mTC-MIBI-SPECT 检查（χ^2＝6．783，P ＝0．010）及单纯 CT 检查（χ^2＝8．012，P ＝0．008）。结论螺旋 CT 多层扫描结合99mTC-MIBI-SPECT 显像在孤立性肺结节病变诊断中效果较好，优于单独使用任意一种扫描方法，可明显提高孤立性肺结节病变临床检出率，值得于临床中进一步推广使用。Objective To discuss the applied value of multislice CT scan in combination with 99 MTC -MI-BI -SPECT for the diagnosis of isolated pulmonary nodule lesions.Methods 60 patients with solitary pulmonary nodules shadow in the X -ray film from July 2014 to August 2015 in our hospital were selected and detected by spiral CT scanning and 99mTC -MIBI -SPECT imaging.Scan results and pathological examination or surgery were com-pared,specificity,sensitivity and accuracy of pulmonary nodules were concluded about the method in the differential diagnosis isolation.Results The specificity,sensitivity and accuracy of multislice spiral CT scanning alone were 73.6%,78.2%,79.3% respectively;The specificity,sensitivity and accuracy of 99mTC -MIBI -SPECT imaging alone,were 82.6%,78.2%,79.3% respectively;The specificity,sensitivity and accuracy of multislice CT scan com-bined with 99mTC -MIBI -SPECT imaging were 93.3%,93.2%,93.8% respectively.The accuracy of combined detection was significantly higher than that of 99mTC -MIBI -SPECT examination（χ^2 =6.783,P =0.010）or CT scan （χ^2 =8.012,P =0.008）.Conclusion Multislice CT scanning combined with 99mTC -MIBI -SPECT imaging has better effect in diagnosing pulmonary nodule lesions,which is superior to the method alone.The combination meth-od can obviously improve the detection rate of lung nodule lesions,which is,worthy of further promotion.

关 键 词：99mTC-甲氧异丁基异腈 亲肿瘤显像 体层摄影术 螺旋 X 线计算机 肺结节 诊断 

分 类 号：R734.2[医药卫生—肿瘤]