水飞蓟宾葡甲胺片对服用抗精神病药导致的肝损伤的疗效及安全性评价  

Safety and efficacy of Silibin Meglumine tablets in the treatment on liver injury induced by antipsychotic drugs

作　　者：徐浩[1] 张国玲[1] 刘义[1] 高蕾[1] 肖玉凤[1] 

机构地区：[1]北京市昌平区中西医结合医院,北京102208

出　　处：《国际精神病学杂志》2016年第5期839-841,875,共4页Journal Of International Psychiatry

摘　　要：目的探讨水飞蓟宾葡甲胺片对抗精神病药所致肝损伤的疗效及安全性。方法收集2014年1月到2015年1月在我院一致的128例服用抗精神病药物所致肝损伤患者,按照随机数字表法分为观察组(64例)和对照组(64例),观察组口服水飞蓟宾葡甲胺片,对照组口服护肝宁片。分别于治疗前、治疗后1个月、3个月、6个月检测两组患者肝功能血清酶学指标和肾功能等指标。结果两组患者治疗前肝肾功能指标,组间无明显差异(P>0.05)。治疗6个月后,两组患者总有效率比较,差异无统计学意义(P>0.05)。两组患者治疗后1个月,3个月和6个月ALT、AST、γ-GT均较治疗前降低(P<0.05),且治疗1个月、3个月观察组上述指标显著低于同时段对照组(P<0.05),但治疗6个月时,两组患者的肝功能间无明显差异(P>0.05);两组患者治疗后Cr较治疗前降低,且观察组Cr显著低于同时段对照组(P<0.05);两组患者治疗前后BUN对比,以及治疗后两组BUN组间比较,差异均无统计学意义(P>0.05)。结论相对于护肝宁片,水飞蓟宾葡甲胺片起效更快且改善作用更明显,且安全性高,值得临床推广。Objective To explore the safety and efficacy of Silibin Meglumine tablets in treatment on liver injury induced by antipsychotic drugs. Methods A total of 128 cases of liver injury patients who induced by antipsychotic drugs treated in our hospital were collected from January 2014 to January 2015.Accorded to the random number table method all the patients were divided into the observation group （64 cases） and the control group （64 cases）. The observation group were treated with Silibin Meglumine tablets, 200mg ;tidthe control group were administrated with Huganning tablets,1.75g tid.The liver function, BUN and Cr levels and other indexes were monitored of the two groups of patients before and after treatment. Results There were no significant differences of liver and renal functions before treatment between the two groups （P 〉 0.05）. After 6 months of treatment, the total effective rates between the two groups were compared, but the difference was not statistically significant （P〉0.05）. 1 month, 3 months and 6 months after treatment the ALT,AST and γ -GT levels of the two groups were significantly lower than those before treatment decreased （P 〈 0.05）, and those liver function indexes mentioned above of the observation group 1 month and 3 months after treatment were significantly lower than those of the control group at the same period （P〈0.05）, but 6 months after treatment, the liver function indexes between the two groups had no significant difference （P 〉 0.05）. Cr levels of the two groups in 1 month, 3 months, 6 months after treatment were lower than those of the two groups before treatment ,and Cr levels of the observation group were significantly lower than that of the control group after treatment （P 〈 0.05）.There were no significant differences of BUN levels of the two groups before and after treatment, and after treatment the differences of BUN levels between the two groups were not statistically significant （P 〉 0.05）. Conclusion Silibin Meglumine tablet

关 键 词：水飞蓟宾葡甲胺 抗精神病药 药物性肝损伤 

分 类 号：R749.05[医药卫生—神经病学与精神病学]