艾司西酞普兰与西酞普兰治疗癫痫合并抑郁障碍患者的对比研究  

The clinical contrast study of escitalopram and citalopram combined with antiepileptic drugs in treatment of epilepsy patients with depression

作　　者：杨建权[1] 汪林涛[1] 赵斌杰[1] 王恒[1] 周毅[1] 

机构地区：[1]湖北医药学院附属人民医院神经外科,十堰442000

出　　处：《国际精神病学杂志》2016年第5期863-866,共4页Journal Of International Psychiatry

摘　　要：目的探讨应用艾司西酞普兰与西酞普兰联合抗癫痫药物治疗癫痫合并抑郁障碍患者的临床疗效与安全性。方法选取我院神经内科2011年3月-2016年3月期间收治的癫痫合并抑郁障碍患者92例，按随机数字表法随机分为观察组（46例）和对照组（46例）。观察组患者给予艾司西酞普兰联合丙戊酸钠治疗，对照组给予西酞普兰联合丙戊酸钠治疗；两组疗程均为4周。观察评估两组患者治疗前及治疗1周、2周、4周后17项汉密尔顿抑郁量表（HAMD-17）及健康问卷抑郁量表（PHQ-9）评分，同时比较两组临床疗效及不良反应。结果（1）治疗前两组患者的HAMD-17及PHQ-9评分差异无统计学意义（P〉0．05），治疗后第1周、2周、4周，观察组的HAMD-17评分及PHQ-9评分均低于对照组（P〈0．05）；（2）观察组的治疗总有效率为95．65％（44／46），显著高于对照组的80．43％（37／46），组间差异有统计学意义（P〈0．05）；（3）两组患者的不良反应差异无统计学意义（P〉0．05）。结论艾司西酞普兰联合抗癫痫药物治疗癫痫合并抑郁障碍的效果优于西酞普兰，起效迅速且安全性高，值得推广应用。Objective To investigate the clinical efficacy and safety of escitalopram and citalopram combined with antiepileptic drugs in treatment of epilepsy patients with depression. Methods A total of 92 cases of epilepsy patients with depression in department of internal neurology ofour hospital from March 2011 to March 2016 were collected.They were randomly divided into two groups： observation group （46 cases） received escitalopram combined with sodium valproate therapy,;control group （46 patients） received citalopram with sodium valproate therapy. Both groups were treated for 4 weeks .The scores of Hamilton Depression Rating Scale 17-item （HAMD） and Patient Health Questionnaire 9-item Depression Scale（PHQ-9） before and 1 week,2week and 4week after treatment were evaluated, and the clinical efficacy and adverse reactions between the two groups were compared. Results （1） Before treatment ,there was no difference in HAMD and PHQ-9 scores between the two groups （P〉0.05）; 1 week, 2 weeks, 4 weeks after treatment , the scores of HAMD-17 and PHQ-9 in observation group were statistically lower than the control group（P〈0.05）;（2） The total effective rate in observation group was 95.65% （44/46）, which was significantly higher than the 80.43% （37/46） in control group （P〈 0.05） ;（3） There was no difference inthe adverse reactions rate between the two groups （P〉 0.05）. Conclusion Escitalopram combined with antiepileptic drugs is more effective on epilepsy patients with depression than citalopram, and has a quick therapeatic effect and higher safety, which should be widely applied.

关 键 词：癫痫 抑郁障碍 抗癫痫药物 艾司西酞普兰 西酞普兰 

分 类 号：R749.05[医药卫生—神经病学与精神病学]