SBRT治疗复发头颈部肿瘤的临床初步应用探讨  

Clinical Application of SBRT in the Treatment of Previouslyirradiated Recurrent Head and Neck Carcinoma

作　　者：张余飞 温居一[1,2] 康静波[1,2] 张新红[2] 方恒虎[2] 

机构地区：[1]安徽医科大学,安徽合肥230032 [2]海军总医院,北京100048

出　　处：《肿瘤学杂志》2016年第10期827-831,共5页Journal of Chinese Oncology

摘　　要：[目的]评估体部立体定向放疗（SBRT）治疗先前接受过放射治疗的复发头颈部鳞癌患者的有效性与安全性。[方法]收集接受SBRT（射波刀）治疗的先前照射过的25例复发头颈部鳞癌患者的临床资料,SBRT的处方剂量是25-36Gy/5-6f。评价指标包括肿瘤缓解率、局部控制率、无进展生存期、生存质量改善率、急性及晚期毒性反应。[结果]射波刀治疗3个月后近期有效（CR＋PR）率为68%,中位无病生存期达10.3个月,1年生存率达48%;治疗过程中及治疗后无4-5级不良反应发生。[结论]对于先前接受过放射治疗的复发头颈部鳞癌患者,射波刀治疗复发头颈部肿瘤近期疗效明确,且不良反应较轻。[Objective]To evaluate the efficacy and safety of cyberknife in the treatment of recurrent head and neck carcinoma. [Methods] 25 cases with previously-irradiated recurrent head and neck carcinoma patients were enrolled,and received 25-36Gy/5-6f of cyberknife. Toxicity and efficiency was assessed during treatment,and 3 months after cyberknife. [Results] 3months after treatment,the total effective rate was 68%,1- year survival rate was 48%,and median PFS was 10.3 months. No grade 4 to 5 toxicities was observed. [Conclusion] Cyberknife in the treatment of previously-irradiated recurrent head and neck carcinoma is efficacy and safety,with mild adverse reactions.

关 键 词：头颈部肿瘤 复发 立体定向放疗 射波刀 

分 类 号：R739.91[医药卫生—肿瘤]