成人高级别脑胶质瘤术后替莫唑胺联合依托泊苷治疗的临床运用与观察  

Clinical application and observation of temozolomide combined with etoposide in postoperative comprehensive treatment of adult high grade glioma

作　　者：夏东彦 张青[1] 马骏[2] 乔冠群[2] 李英斌[2] 

机构地区：[1]南京医科大学第二临床医学院,南京210011 [2]南京医科大学第二附属医院神经外科

出　　处：《临床神经外科杂志》2016年第5期340-343,共4页Journal of Clinical Neurosurgery

基　　金：南京市科技计划基金资助项目(201303042)

摘　　要：目的比较替莫唑胺联合依托泊苷与单用替莫唑胺在成人高级别脑胶质瘤术后综合治疗中的疗效差异。方法 42例成人高级别脑胶质瘤患者行手术切除病灶,术后随机分为两组,单药组(单用替莫唑胺)和联合治疗组(替莫唑胺联合依托泊苷)。比较两组患者的无进展生存期及不良反应。结果单药组和联合治疗组的中位无进展生存时间分别为17.5周和24.4周,6个月无进展生存率分别为31.8%和45.0%。联合治疗组的无进展生存期和6个月无进展生存率均要明显高于单药组(均P<0.05)。同时,两组患者的不良反应无显著差异。结论在成人高级别脑胶质瘤术后综合治疗中,替莫唑胺联合依托泊苷的化疗疗效要优于单用替莫唑胺治疗,该方案值得临床推广。Objective To compare the difference of curative effects between temozolomide combined with etoposide and temozolomide in the postoperative comprehensive treatment of adult high grade glioma. Methods 42 adult-patients with the high grade glioma,who received surgery,were divided randomly into two groups,the single drug group（ only temozolomide） and the united drug group（ temozolomide combined with etoposide）. The progressive free survival（ PFS） and adverse effects were observed retrospectively. Results The median PFS of the single drug group and the united drug group was 17. 5 weeks and 24. 4 weeks. The PFS-6 months of the single drug group and the united drug group was 31. 8% and 45. 0%. So the PFS and PFS-6 months of the united drug group is obviously higher than that of the single drug group（ P〈 0. 05）. Meanwhile adverse effects between this two groups had no obviously differences. Conclusion In the postoperative comprehensive treatment of adult high grade glioma,the curative effect of temozolomide combined with etoposide is better than temozolomide. The plan is worthy of clinical promotion.

关 键 词：替莫唑胺 依托泊苷 成人 高级别脑胶质瘤 疗效 不良反应 

分 类 号：R739.41[医药卫生—肿瘤]