帕金森病脑部葡萄糖代谢和脑多巴胺转运体PET显像特点的临床研究  

Clinical study of brain glucose metabolism and brain dopamine transporter PET imaging in patients with Parkinson＇s disease

作　　者：许靖[1] 李肖红[1] 秦永德[1] 张奇洲[1] 李毓斌[1] 刘立水[1] 谢彬[1] 

机构地区：[1]新疆医科大学第一附属医院核医学科,乌鲁木齐830011

出　　处：《国际放射医学核医学杂志》2016年第5期338-344,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：新疆维吾尔自治区科技计划项目（201417101）

摘　　要：目的 探讨18F-FDG脑代谢联合11C-甲基-N-2β-甲基酯-3β（4-F苯基）托烷（11C-CFT）脑多巴胺转运体（DAT）PET双显像在帕金森病（PD）诊断与病情严重程度评估中的应用价值.方法 对55例不同严重程度的PD患者及30名健康对照者分别行18F-FDG脑代谢显像和11C-CFT脑DATPET显像检查,通过勾画ROI,比较PET图像中不同严重程度的PD患者与健康对照者中脑基底节区葡萄糖代谢及DAT分布的差异,分析18F-FDG PET、11C-CFT PET显像在不同严重程度PD评估中的作用及特点.结果 与健康对照者相比,18F-FDG PET显像中PD患者脑葡萄糖代谢改变主要为双侧基底节区壳核对称性代谢增高,同时部分患者伴有大脑皮质不同程度代谢减低;11C-CFT PET显像中PD患者双侧尾状核、壳核前、中、后部表现为DAT分布不同程度减低.单侧症状者或双侧症状者均以患侧对侧基底节区壳核DAT分布减低明显,并以壳核后部DAT分布减低为著.结论 18F-FDGPET联合11C-CFT PET双显像在PD诊断及病情严重程度评估中有应用价值.Objective To explore 18F-FDG brain metabolism and 11C-2β-carbomethoxy-3β-（4-fluorophenyl） tropane （11C-CFT） brain dopamine transporter（DAT） PET dual imaging in the diagnosis and evaluation of the severity of Parkinson＇s disease （PD）.Methods Fifty-five patients with different severity of PD and 30 cases of healthy controls were subjected to 18F-FDG cerebral metabolic imaging and 11C-CFT DAT PET imaging examination,in which ROI were outlined to compare the differences in glucose metabolism and DAT distribution in the basal ganglia of PD with different severity among the patients and those of healthy controls based on the PET images.18F-FDG PET and 11C-CFT PET imaging were used to assess severity of PD.Results By comparison with the healthy controls,18F-FDG PET imaging indicates that the changes in brain metabolism caused by PD mainly show improvement in symmetry of bilateral basal ganglia putamen.Moreover,some PD cases are accompanied with reduction in the metabolism of cerebral cortex to varying degrees.11C-CFT PET imaging in PD patients indicates that DAT distribution in their bilateral caudate nucleus,bilateral anterior putamen,medio-putamen,and posterior putamen decreased in different degrees.Based on the symptoms of unilateral or bilateral PD,DAT distribution on the contralateral basal ganglia putamen decreased,whereas posterior putamen DAT distribution decreased more prominently.Conclusion 18F-FDG PET and 11C-CFT PET imaging dual joint inspection has a significant value in diagnosing and assessing the severity of PD.

关 键 词：帕金森病 葡萄糖 正电子发射断层显像术 氟脱氧葡萄糖F18 多巴胺转运体 

分 类 号：R742.5[医药卫生—神经病学与精神病学]