肝纤维化影像学及血清学诊断方法的研究进展  

Advances in imaging and serological diagnosis of hepatic fibrosis

作　　者：叶凡豪 李显文[1] 杨孟雪[1] 李凤萍[1] 安小娟 李娅[1] 

机构地区：[1]遵义医学院附属医院内分泌科,贵州遵义563003

出　　处：《分子影像学杂志》2016年第4期425-427,共3页Journal of Molecular Imaging

基　　金：国家自然科学基金(NO:81560147);贵州省科技攻关项目[黔科合SY字(2012)3116号];贵州省科学技术基金项目[黔科合J字LKZ(2013)53号];遵义医学院博士启动基金(F-588)

摘　　要：肝纤维化本质上是肝脏反复发生弥漫性损伤—修复,是慢性肝脏疾病发展为肝硬化的必经阶段。预防肝纤维化发生、阻止肝纤维化发展,对肝硬化甚至肝癌的发生具有重要意义,但是肝纤维化的早期发现、诊断存在困难。肝组织活检是金标准,但是因其创伤性等难以推广。随着科技不断发展和对肝脏损伤—肝纤维化—肝癌发生、发展过程的认识不断加深,各种无创性诊断肝纤维化方法不断被提出及广泛应用。现就对此类技术的研究进展作一综述。Hepatic fibrosis is a recurrent and diffuse lesion in the hepar, and it is a necessary stage in the development of chronic hepatic disease. Prevention of the occurrence and development of hepatic fibrosis has important significance to hepatic cirrhosis and even hepatocarcinoma, but the early discovery and diagnosis of the hepatic fibrosis presents some difficulty.Though liver biopsy is the gold standard, it is difficult to be popularized because of its trauma. With the continuous development of science and technology, and the deepening understanding of the occurrence and development of hepatic damage, hepatic fibrosis and hepatocarcinoma, all kinds of non-invasive methods for diagnosis of hepatic fibrosis have been proposed and widely used. This paper reviews the research progress of these techniques.

关 键 词：肝纤维化 血清学 影像学 诊断 

分 类 号：R575.2[医药卫生—消化系统]