男性尿道口尖锐湿疣患者人乳头瘤病毒分型与复发关系的临床研究  

Observation of the relapse rates of condyloma acuminatum with different human papillomavirus genotypes in male urethral meatus

作　　者：李文海[1] 贾军[1] 蔡林[1] 慕彰磊[1] 王凌霞[1] 单艳霞[1] 才桂春 张文革[1] 张建中[1] 

机构地区：[1]北京大学人民医院皮肤科,北京100044

出　　处：《中国艾滋病性病》2016年第10期813-816,共4页Chinese Journal of Aids & STD

摘　　要：目的探讨男性尿道口尖锐湿疣患者人乳头瘤病毒(HPV)感染基因分型情况,以及不同基因型别与临床复发的关系,了解男性尿道口尖锐湿疣合并高危亚型HPV感染状况,为女性宫颈HPV感染预防提供新的思路。方法采用基因扩增结合基因芯片杂交技术检测了68例男性尿道口尖锐湿疣患者皮损中的HPV,CO2激光治疗后随访6个月,研究不同基因型别与临床复发的关系。结果 68例男性尿道口尖锐湿疣皮损中,67例检测出HPV阳性,占98.5%,共检出15种HPV基因亚型,以HPV11(46例,占68.7%)和HPV6(35例,占52.2%)为主,检出病例数从高到低依次为HPV11>HPV6>HPV16>HPV18>HPV35、52、58>HPV42、43、33、59。在67例HPV阳性患者中,低危型HPV感染44例,占65.7%,以HPV11和(或)HPV6为主;高低危型HPV感染23例,占34.3%,其中21例为高低危型HPV混合感染,2例为单纯高危型HPV感染。67例患者经CO2激光治疗后随访6个月,高低危型HPV感染组复发率为87.0%,单纯低危型HPV感染组复发率为63.6%,两者差异有统计学意义(P<0.05)。结论北京男性尿道口尖锐湿疣HPV基因型主要以低危型HPV6、11为主,高危型HPV感染大多合并低危型HPV感染,高低危型HPV感染组尿道口尖锐湿疣临床复发率明显高于单纯低危型HPV感染组。Objective To investigate the genotype spectrum of human papillomavirus（HPV）among male patients with condyloma acuminatum（CA）in male urethral meatus in Beijing,and its relationship with clinical relapse rate so as to understand the status of high risk HPV infection in male urethral meatus,and to provide a new view for prevention of female cervical HPV infection.Methods 68 samples of patients with CA in male urethral meatus were detected by gene amplification combined with gene chip hybridization.The correlation of the HPV genotypes with its recurrence was determined.Results 67（98.5%）out of 68 patients were HPV positive,and a total of 15 HPV subtypes were identified.HPV 11（46cases,68.7%）and HPV 6（35cases,52.2%）were the predominant ones,sequentially followed by HPV 16,HPV 18,HPV 35/52/58 and HPV 42/43/33/59.Of the HPV-positive specimens,44（65.7%）patients harbored low risk HPV subtypes（HPV 11and/or HPV 6）;and 23（34.3%）harbored high risk ones.21 patients suffered multiple infection by both high risk and low risk subtypes.During the 6-month follow-up after CO2 laser treatment,recurrence was observed by 87% of patients in high risk group and 63.6%in low risk group（P〈0.05）.Conclusion Low risk subtypes of HPV,mainly HPV 6and HPV 11,are the predominant pathogens in male urethral meatus CA patients in Beijing.High risk HPV infection is usually complicated with low risk subtypes.The clinical relapse rate of CA is significantly higher in high risk and low risk HPV infection cases than in only low risk HPV infection cases.

关 键 词：尖锐湿疣 人乳头瘤病毒 男性尿道口 基因型 

分 类 号：R737.33[医药卫生—肿瘤]