阻塞性睡眠呼吸暂停低通气综合征并发脑梗死患者相关炎性指标的临床研究  

Clinical Studies of the Inflammatory Markers in Patients with Obstructive Sleep Apnea-Hypopnea Syndrom Complicated by Cerebral Infarction

作　　者：李慧[1] 贾良勇[1] 冯莉[1] 雷光星[1] 王兴宁[1] 

机构地区：[1]延安大学附属医院检验科

出　　处：《现代检验医学杂志》2016年第5期50-54,共5页Journal of Modern Laboratory Medicine

基　　金：国家高新技术研究发展计划(863计划)课题资助,课题编号:2011AA02A111

摘　　要：目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者及并发脑梗死患者同型半胱氨酸（Hcy）、超敏 C-反应蛋白（hs-CRP）、白细胞介素-6（IL-6）水平的变化。方法选取55例 OSAHS患者及56例脑梗死患者，通过多导睡眠监测将所有OSAHS患者分为轻度、中度和重度三组，并将所有患者分为单纯OSAHS组、单纯脑梗死组及OSAHS并发脑梗死组，测定所有患者睡眠呼吸暂停低通气指数（AHI）、最低血氧饱和度（LSpO2）、平均血氧饱和度（MSpO2）、睡眠呼吸暂停最长时间（LAT）及Hcy，hs-CRP和IL-6水平，并与30例对照组进行比较。结果单纯OSAHS组及单纯脑梗死组与对照组相比，以及 OSAHS并发脑梗死组与单纯 OSAHS组及单纯脑梗死组相比，AHI，LAT，Hcy，hs-CRP和 IL-6均显著增高，LSpO2及 MSpO2均显著降低，差异有统计学意义（P＜0.05）。随着 OSAHS病情的加重，Hcy，hs-CRP和 IL-6均逐渐增高。OSAHS患者的 Hcy，hs-CRP，IL-6与 AHI呈正相关，相关系数分别为0.751，0.678和0.635（P＜0.001）。结论OSAHS与脑梗死发生发展密切相关，动态监测 Hcy，hs-CRP和 IL-6水平对于评价患者的病情及疗效有一定的参考价值。Objective To investigate the change of homocysteine （Hcy）,high sensitive C-reactive protein （hs-CRP）and Inter-leukin 6 （IL-6）in patients with Obstructive Sleep Apnea-Hypopnea Syndrome （OSAHS）complicated by Cerebral Infarction （CI）.Methods Chose 55 patients with OSAHS and 56 patients with CI.All patients with OSAHS were divided into mild group,moderate group and severe group by polysomnography,and all patients were divided into simple OSAHS group,sim-ple CI group and OSAHS complicated by CI group.All the patients’sleep apnea hypoventilation index （AHI）,the lowest oxygen saturation （LSpO2 ）,average blood oxygen saturation （MSpO2 ）,sleep apnea the longest （LAT）and the level of Hcy,hs-CRP,IL-6 were determined,and compared with 30 cases of control group.Results The AHI,LAT,Hcy,hs-CRP and IL-6 of simple OSAHS group and simple CI group were obviously higher than that in control group,LSpO2 ,MSpO2 were obviously lower,the differences were statistical significant （P〈0.05）.The AHI,LAT,Hcy,hs-CRP and IL-6 of OS-AHS complicated by CI group were obviously higher than that in simple groups,but LSpO2 and MSpO2 were obviously low-er,and the differences were statistical significant （P〈0.05）.With the aggravation of OSAHS,Hcy,hs-CRP and IL-6 were gradually increased.Hcy,hs-CRP and IL-6 were positively correlated with AHI in patients with OSAHS,correlation coeffi-cient were 0.751,0.678 and 0.635,respectively （P〈0.001）.Conclusion OSAHS was closely related to the occurrence and development of CI,the dynamic monitoring of Hcy,hs-CRP and IL-6 levels has a certain reference value for evaluation of therapeutic effect.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 脑梗死 同型半胱氨酸 超敏C-反应蛋白 白细胞介素-6 

分 类 号：R743[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]