超敏甲状腺球蛋白测定在分化型甲状腺癌随访中的应用  

Application of ultrasensitive thyroglobulin assays in the follow-up of differentiated thyroid carcinoma

作　　者：魏伟军[1] 沈晨天 宋红俊[1] 邱忠领[1] 罗全勇[1] 

机构地区：[1]上海交通大学附属第六人民医院核医学科,200030

出　　处：《中华核医学与分子影像杂志》2016年第5期474-478,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：DTC是最常见的内分泌肿瘤,其常规治疗包括手术及131I治疗.目前,标准的DTC随访监测项目包括血清Tg测定和颈部超声检查,必要时可行131I全身显像.甲状腺细胞是体内Tg的唯一来源,外周循环血中的Tg可作为DTC随访中预示肿瘤持续存在或复发转移的特异性生化指标.近年来Tg测定方法的灵敏度和精确度显著提高,使低水平或超低水平Tg的测定成为可能.为此,笔者对各种超敏Tg测定方法及其应用进行综述.DTC is the most common endocrine carcinoma and its routine treatment consists of total thyroidectomy and 131I thyroid remnant ablation.Currently,standard follow-up for DTC comprises Tg measurement and neck ultrasound as well as an additional radioiodine scan when indicated.As thyroid cells are assumed to be the only source of Tg in serum,circulating Tg serves as an excellent marker of persistent or recurrent disease in DTC follow-up.With the development of highly sensitive Tg assays,now it is possible to detect very low Tg concentrations which reflect minimal amounts of thyroid tissue without the need for TSH stimulation.This review is to introduce clinical implications of highly sensitive Tg assays.

关 键 词：甲状腺肿瘤 甲状腺球蛋白 发展趋势 

分 类 号：R736.1[医药卫生—肿瘤]