Slug在甲状腺乳头状癌中的表达及其临床意义  

Expression and significance of Slug in papillary thyroid carcinomas

作　　者：张学东[1] 陈士超[1] 焦德[2] 洪虹[3] 温文娟[1] 闫金强[1] 

机构地区：[1]山东省聊城市人民医院病理科,252000 [2]山东省聊城市人民医院甲状腺外科,252000 [3]山东省聊城市人民医院,肾内科252000

出　　处：《实用医学杂志》2016年第19期3197-3199,共3页The Journal of Practical Medicine

基　　金：聊城市卫计委自筹经费项目(编号:2015-116)

摘　　要：目的:观察甲状腺乳头状癌(PTC)及其癌旁组织中Slug蛋白的表达,并探讨其临床意义。方法:采用VENTANA自动免疫组化仪检测107例PTC及癌旁正常甲状腺组织中Slug蛋白的表达,观察其在PTC中的表达及其与各临床病理参数之间的关系。结果:PTC及癌旁甲状腺组织中Slug表达的阳性率分别为65.4%(70/107)、14.0%(15/107),两者比较差异有统计学意义(P<0.001)。PTC中Slug蛋白的高表达与癌的被膜侵犯和淋巴结转移情况相关(P<0.05)。结论:Slug蛋白在PTC中高表达,并且与包膜侵犯和淋巴结转移相关,推测其在判断肿瘤的转移和预后方面有一定的临床意义。Objective To explore the clinical significance of Slug expression in papillary thyroid carci-noma（PTC）. Methods Employed Ventana immunohistochemistry assay to determine the expression of Slug in 107 cases of PTC and para-tumorous normal tissue. The relationship with Slug expression in PTC and clinico-pathology data were also analyzed. Results Expression of Slug in PTC （65.4%, 70/107）and para-tumorous nor-mal tissue （14.0%,15/107）were statistically different （P 〈 0.001）. Overexpression of Slug in PTC was signifi-cantly associated with capsular invasion and lymph node metastasis （P 〈 0.05）. Conclusion Overexpression of Slug in PTC is associated with capsular invasion and lymph node metastasis , these may suggest some clinical significance of Slug expression in PTC in predicting lymph node metastasis and prognosis.

关 键 词：甲状腺乳头状癌 临床病理 预后 

分 类 号：R736.1[医药卫生—肿瘤]