原发性膀胱小细胞癌的诊断和治疗  

Primary small cell carcinoma of the bladder: 7 cases report and literature review

作　　者：薛森耀 王晓[1] 钟修龙[1] 王振林[1] 于维冯 赵凯[1] 董大海[1] 杨晓坤[1] 

机构地区：[1]青岛大学附属医院泌尿外科,青岛266003

出　　处：《中华腔镜泌尿外科杂志（电子版）》2016年第5期17-20,共4页Chinese Journal of Endourology(Electronic Edition)

摘　　要：目的探讨原发性膀胱小细胞癌(SCCB)的临床特点、诊疗方法和预后情况。方法回顾性分析2007年4月至2014年5月,青岛大学附属医院泌尿外科收治的7例SCCB患者的临床资料及随访结果。其中男5例,女2例,中位年龄65岁。7例患者均以无痛肉眼血尿就诊,均行手术治疗。4例患者行TURBT手术,1例患者行膀胱部分切除术+同侧髂血管淋巴结清扫术,1例患者行全膀胱切除+双侧输尿管造口术,1例患者行双侧输尿管皮肤造口术。结果术后病理结果为SCCB或伴SCCB的复合性癌。免疫组化结果神经元特异性烯醇化酶均(+),1例突触素(-),3例嗜铬蛋白颗粒(+)。5例患者死于全身肿瘤转移,2例分别随访16个月和35个月,目前仍存活,未见复发或转移。结论SCCB是一种罕见的膀胱恶性肿瘤,手术联合化疗可提高疗效,改善预后。Objective To discuss the clinical features, diagnosis,treatment and prognosis of primary small cell carcinoma of the bladder （SCCB）. Methods The clinical data and follow-up results of 7 cases including 5 males and 2 females with the mean age of 65 years of SCCB were retrospectively analyzed from April 2007 to May 2014 in Affiliated Hospital of Qingdao University. All patients presented with symptoms of painless gross hematuria and accepted surgery. Four patients received transurethral resection of bladder minor （TURBT）. One patient received partial cystectomy. One patient received radical cystectomy and 1 patient received cutaneous ureterostomy. Results Pathology examination confirmed the diagnosis of SCCB or mixed with SCCB. In immunohistochemical essay, all cases were NSE（＋）, 1 case Syn（-） and 3 cases CgA （＋）. All the 7 patients were followed up. Five cases died of the carcinoma relapse. The other 2 cases are still alive after 16 and 35 months follow up. Conclusions SCCB is a rare tumor with high malignancy and poor prognosis. Surgery combined with chemotherapy can increase the cure rate.

关 键 词：膀胱肿瘤 诊断 切除术 化学疗法 

分 类 号：R737.14[医药卫生—肿瘤]