大肠癌中血管内皮生长因子-A的表达与淋巴管密度、微血管密度的关系研究  

Expression of vascular endothelial growth factor-A and its role in micro vessel formation and lymphatic formation in colorectal cancer

作　　者：蒋华锋[1] 应晓江[1] 陈洪亮[1] 王晓燕[2] 

机构地区：[1]绍兴市人民医院肛肠外科,浙江绍兴312000 [2]绍兴市人民医院肿瘤放疗科

出　　处：《中华全科医学》2016年第11期1870-1872,共3页Chinese Journal of General Practice

摘　　要：目的探析大肠癌中血管内皮生长因子-A(VEGF-A)表达与淋巴管密度(LVD)、微血管密度(MVD)间的关系。方法收集2011年4月—2015年2月本院治疗的79例大肠癌患者资料,其中52例直肠癌患者,27例结肠癌患者。分析大肠癌临床病理特征与LVD计数的关系、MVD和LVD与大肠癌内VEGF-A表达的关系以及MVD与LVD的关系。结果正常组织内的LVD明显低于大肠癌组织;LVD与淋巴管内癌栓关系密切(P<0.05),而与大肠癌的淋巴结转移、TNM分期、分化程度以及浸润深度无关(P>0.05)。肿瘤组织内VEGF-A表达与MVD(CD34计数)关系密切(P<0.05),与LVD(podoplanin计数)无关(P>0.05)。大肠癌组织内的LVD明显低于MVD(P<0.01),但是LVD计数与MVD计数无关(P>0.05)。结论淋巴管的形成与大肠癌关系密切,淋巴管形成与微血管形成可能是互相独立的两个过程;大肠癌组织内VEGF-A可以对微血管的形成起诱导作用,但其与淋巴管形成无显著关系;大肠癌中LVD值明显低于MVD,但两者关系不明显。Objective To analyze the relationship between vascular endothelial growth factor-A （VEGF-A） expressions and the density of Lymphatic vessel and micro vessel （ LVD and MVD）. Methods A total number of 79 patients with eolorectal cancer in our hospital from 2011 to 2015,including 52 cases of rectal carcinoma and 27 cases of colon carcino- ma,were collected. The connection between the clinical pathological features and the value of LVD, the relationship be- tween the expressions of VEGF-A and the levels of MVD and LVD,the relationship between LVD and MVD were ana- lyzed. Results The value of LVD in normal tissues was obviously lower than that in colon cancer tissues. LVD had close correlation with lymphatic vessel tumor thrombus （P 〈 0.05 ） , had no correlation with lymph node metastasis, TNM stage, differentiation degree and depth of invasion of coloreetal cancer（ P 〉 0.05 ）. The expression of VEGF-A in tumor tissues had close correlation with MVD （CD34 count）, P 〈 0.05, but had no correlation with LVD （podoplanin count）, P 〉 0.05. The value of LVD was obviously lower than MVD in colon cancer（ P 〈 0.01 ）. But LVD count had no correlation with MVD count （ P 〉 0.05 ）. Conclusion The lymphatic formation plays an important role in the whole development process of colorectal cancer. Micro vessel formation and lymphatic formation may be two processes that are independent of each other. The VEGF-A has induction effect on micro vessel formation in eoloreetal cancer, but it has no correlation with lym- phatic formation. LVD value is obviously lower than MVD value in colorectal cancer, but their relationship is not obvious.

关 键 词：大肠癌 血管内皮生长因子-A 淋巴管密度 微血管密度 

分 类 号：R735.34[医药卫生—肿瘤] R730.231[医药卫生—临床医学]