松果体钙化对首发精神分裂症患者的临床诊断价值  

Clinical diagnostic value of pineal calcification in patients with first episode schizophrenia

作　　者：程祖胜 夏瑞明[2] 夏国园[2] 曹世林 诸绍锋 戚洪阳 王爱芝[4] 

机构地区：[1]绍兴市第七人民医院放射科,浙江绍兴312000 [2]绍兴文理学院医学院,浙江绍兴312000 [3]绍兴市第七人民医院精神科 [4]绍兴市人民医院心内科,浙江绍兴312000

出　　处：《中华全科医学》2016年第11期1927-1931,共5页Chinese Journal of General Practice

基　　金：绍兴文理学院医学院人才基金(2014-A2)

摘　　要：目的研究松果体钙化(PC)对首发精神分裂症(FES)患者的临床诊断价值。方法回顾性分析220例经临床确诊的FES患者的脑部CT图像,观察FES患者的松果体有无钙化,同时测量其钙化大小,并与对照组(n=200)进行对照研究。按照临床分型患者组分两亚组:偏执型组和非偏执型组。经统计学处理后分析:1PC在患者组与对照组之间的差异。2PC在偏执型组与非偏执型组中的差异。3PC在患者组与对照组男女之间的差异。4患者组中PC发生率及钙化大小与年龄相关性。结果 1患者组PC 139例,其中男性71例,女性68例,发生率为63.18%(139/220);对照组PC 90例,其中男性41例,女性49例,发生率45%(90/200)。FES患者PC发生率明显高于对照组(χ2=13.97,P=0.001)。2偏执型组与非偏执型组PC发生率差异无统计学意义(χ2=0.28,P=0.60)。3PC在患者组与对照组男女性别之间差异无统计学意义(χ2=0.88,P=0.35;χ2=0.25,P=0.62)。4患者组钙化大小在18岁之前随患者年龄增加而增大,呈正相关(r=0.96,P<0.001),与对照组相比,松果体在FES患者中存在过早钙化。结论 FES患者PC的发生率高于对照组,PC对FES早期临床诊断具有一定参考价值。Objective To investigate the clinical diagnostic value of pineal calcification（PC） in patients with first episode schizophrenia（FES）. Methods The brain CT image of 220 cases who were diagnosed FES clinically were retrospective analyzed to observe whether the pineal has calcification and to measure its size. Meanwhile, compared with the healthy matched groups（ n = 200）. Patients were divided into two subgroups according to the clinical classification： paranoia and non-paranoia group. After statistical treatment：①Analysis of the differences of PC between the patients and the controls. ②The differences of PC between paranoia and non-paranoia group of FES. ③The differences of PC between the gender of male and female in patients and groups. ④ The correlation between the size of the PC and the age of the patients. Results ①There were 139 cases （ male 71, female 68 ） with PC in the FES patients, the incidence of PC was 63.18% （139/220）. However, there were only 90 cases （ male 41, female 49 ） of PC in the control groups, the incidence was 45 % （90/200）. The incidence of PC in FES patients was significantly higher than that in control group （χ2 = 13.97, P = 0. 001 ）. ②There was no significant difference in the incidence of PC between paranoia and non-paranoia group of FES （χ2 = 0.28,P = 0.60）. ③There was no significant difference in the incidence of PC between the gender of male and fe- male（ χ2 = 0. 88 ,P = 0.35;χ2 = 0.25 ,P = 1. 62）④The size of PC in FES patients increased with the age before the age of 18, and was positively correlated （r = 0.96, P 〈 0.001 ）. The pineal gland was calcifieated earlier in FES patients com- pared with the controls. Conclusion The incidence of PC in FES patients was higher than that in the control groups, PC has a certain reference value for the early clinical diagnosis of FES.

关 键 词：首发精神分裂症 松果体 钙化 CT 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R322.55[医药卫生—临床医学]